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Prevalence of MDR organism (MDRO) carriage in children and their household members in Siem Reap Province, Cambodia
- Source :
- JAC-Antimicrobial Resistance
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- BackgroundThe rising incidence of infections caused by MDR organisms (MDROs) poses a significant public health threat. However, little has been reported regarding community MDRO carriage in low- and middle-income countries.MethodsWe conducted a cross-sectional study in Siem Reap, Cambodia comparing hospital-associated households, in which an index child (age: 2–14 years) had been hospitalized for at least 48 h in the preceding 2–4 weeks, with matched community households on the same street, in which no other child had a recent history of hospitalization. Participants were interviewed using a survey questionnaire and tested for carriage of MRSA, ESBL-producing Enterobacterales (ESBL-E) and carbapenemase-producing Enterobacterales (CPE) by culture followed by antibiotic susceptibility testing. We used logistic regression analysis to analyse associations between collected variables and MDRO carriage.ResultsForty-two pairs of households including 376 participants with 376 nasal swabs and 290 stool specimens were included in final analysis. MRSA was isolated from 26 specimens (6.9%). ESBL-producing Escherichia coli was detected in 269 specimens (92.8%) whereas ESBL-producing Klebsiella pneumoniae was isolated from 128 specimens (44.1%), of which 123 (42.4%) were co-colonized with ESBL-producing E. coli. Six (2.1%) specimens tested positive for CPE (4 E. coli and 2 K. pneumoniae). The prevalence ratios for MRSA, ESBL-producing E. coli and ESBL-producing K. pneumoniae carriage did not differ significantly in hospital-associated households and hospitalized children compared with their counterparts.ConclusionsThe high prevalence of ESBL-E across both household types suggests that MDRO reservoirs are common in the community. Ongoing genomic analyses will help to understand the epidemiology and course of MDRO spread.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
medicine.drug_class
Klebsiella pneumoniae
030106 microbiology
Immunology
Antibiotics
medicine.disease_cause
Logistic regression
Microbiology
03 medical and health sciences
0302 clinical medicine
Environmental health
Epidemiology
medicine
AcademicSubjects/MED00740
Immunology and Allergy
030212 general & internal medicine
biology
business.industry
Public health
Incidence (epidemiology)
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Methicillin-resistant Staphylococcus aureus
AcademicSubjects/MED00290
Infectious Diseases
Carriage
Original Article
AcademicSubjects/MED00230
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- JAC-Antimicrobial Resistance
- Accession number :
- edsair.doi.dedup.....3033a1601fdc4f3144548478e02f47f8