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Estrogen receptor α36 mediates a bone-sparing effect of 17β-estrodiol in postmenopausal women
- Source :
- Journal of Bone and Mineral Research
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Recently, a membrane-based estrogen receptor (ER), ER-α36, was identified and cloned that transduces membrane-initiated estrogen signaling such as activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway. Here we show that the postmenopausal level of estradiol (E2) induces mitogenic, antiapoptotic, and antiosteogenic effects and proapoptotic effects in postmenopausal osteoblasts and osteoclasts with high levels of ER-α36 expression, respectively. We also found that ER-α36 mediated the effects of postmenopausal-level E2 on proliferation, apoptosis, and differentiation of osteoblasts through transient activation of the MAPK/ERK pathway, whereas ER-α36-mediated postmenopausal-level E2 induces apoptosis of osteoclasts through prolonged activation of the MAPK/ERK pathway with the involvement of reactive oxygen species. We also show that the levels of ER-α36 expression in bone are positively associated with bone mineral density but negatively associated with bone biochemical markers in postmenopausal women. Thus the higher levels of ER-α36 expression are required for preserving bone mass in postmenopausal and menopausal women who become osteoporotic if ER-α36-mediated activities are dysregulated. © 2011 American Society for Bone and Mineral Research.
- Subjects :
- Adult
MAPK/ERK pathway
medicine.medical_specialty
Bone density
Endocrinology, Diabetes and Metabolism
Osteoclasts
Estrogen receptor
Apoptosis
Biology
Bone and Bones
Bone remodeling
Tissue Culture Techniques
Bone Density
Osteogenesis
Osteoclast
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
RNA, Messenger
ESTROGEN RECEPTOR α36
Extracellular Signal-Regulated MAP Kinases
OSTEOBLAST
Flavonoids
OSTEOCLAST
Osteoblasts
Estradiol
Estrogen Receptor alpha
Osteoblast
Middle Aged
Enzyme Activation
Postmenopause
Endocrinology
medicine.anatomical_structure
Female
Original Article
Bone Remodeling
Mitogens
Signal transduction
Reactive Oxygen Species
Estrogen receptor alpha
Biomarkers
BONE MINERAL DENSITY
Subjects
Details
- ISSN :
- 08840431
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Bone and Mineral Research
- Accession number :
- edsair.doi.dedup.....3034e5119b33d2c20a9e4d58c0d4213f