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Dynamic changes of the composition of plasma HDL particles in patients with cardiac disease: Spotlight on sphingosine-1-phosphate/serum amyloid A ratio
- Source :
- Clinical and Experimental Pharmacology and Physiology. 45:319-325
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Several epidemiological studies reported an inverse relationship between plasma high-density lipoprotein (HDL) cholesterol levels and atherosclerotic cardiovascular disease (ASCVD). However, therapeutic interventions targeted at raising HDL-cholesterol failed to improve cardiovascular outcomes, suggesting that HDL components distinct from cholesterol may account for the anti-atherothrombotic effects attributed to this lipoprotein. Sphingosine-1-phosphate (S1P) and the acute phase protein serum amyloid A (SAA) have been identified as integral constituents of HDL particles. Evidence suggests that S1P and SAA levels within HDL particles may be affected by inflammation and oxidative stress, which are coexisting processes underlying ASCVD. Because SAA, an inflammation-related marker, and S1P, an anti-atherothrombotic marker, have relatively clear opposite characteristics among the HDL-associated proteins, the approach of assessing the two markers simultaneously may provide new insights in clinical practice (S1P/SAA Index). This review focuses on evidence in support of the concept that the S1P/SAA Index may affect the HDL atheroprotective properties and may, therefore represent a potential target for therapeutic interventions.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Heart Diseases
Physiology
Inflammation
030204 cardiovascular system & hematology
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Sphingosine
Physiology (medical)
Internal medicine
medicine
Humans
Sphingosine-1-phosphate
Serum amyloid A
Pharmacology
Serum Amyloid A Protein
Cholesterol
business.industry
Cholesterol, HDL
Acute-phase protein
030104 developmental biology
Endocrinology
chemistry
lipids (amino acids, peptides, and proteins)
Lysophospholipids
medicine.symptom
business
Oxidative stress
Lipoprotein
Subjects
Details
- ISSN :
- 03051870
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi.dedup.....306ebeccb6007bb63e2afb7c177efaa1