Amantadine toxic effect and acute psychosis – a case report

GRUCA, Dariusz, ANTONIAK, Krzysztof, WAIS, Marcin & ZAJĄC, Marlena. Amantadine toxic effect and acute psychosis – a case report.Journal of Education, Health and Sport. 2023;13(3):85-89. eISSN 2391-8306. DOIhttp://dx.doi.org/10.12775/JEHS.2023.13.03.012 https://apcz.umk.pl/JEHS/article/view/41594 https://zenodo.org/record/7553880 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 30.12.2022. Revised: 17.01.2023. Accepted: 20.01.2023. Amantadine toxic effect and acute psychosis – a case report Dariusz Gruca1,Krzysztof Antoniak1, Marcin Wais1, Marlena Zając1, 1Studenckie Koło Naukowe przy Klinice Toksykologii, Uniwersytet Medyczny w Lublinie Dariusz Gruca; dariusz.gruca1@gmail.com; ORCID: 0000-0002-5583-1229; Krzysztof Antoniak; krzyss.anton@gmail.com; ORCID: 0000-0001-8065-081X Marcin Wais; marcin.wais0805@gmail.com; ORCID: 0000-0003-4757-8582 Marlena Zając; marlenzajac11@gmail.com; ORCID:0000-0002-6251-0175; Abstract: Introduction and purpose:The pandemic of COVID-19 has induced patients to use different ways to struggle with SARS-CoV-2 infection. Amantadine has become more popular as a supportive drug in the treatment of COVID-19 symptoms. This report presents a case of a young, previously healthy woman hospitalized in the Toxicology and Cardiology Department because of acute psychosis induced by amantadine intoxication. Brief description of the state of knowledge:Acute psychosis can be caused by several medications, including psychostimulants, antibiotics, antivirals, and antiparkinsonians. Amantadine has primarily dopaminergic with some anticholinergic properties and is used predominantly as an adjuvant agent in the management of Parkinson's disease treatment. Psychomotor agitation, insomnia, excessive verbosity, delusions, and behavioral disturbances which are typical toxic effects of amantadine primarily affecting the central nervous system which were presented by patient described in this case report. Conclusions:Our case illustrates the negative effects of amantadine on the central nervous system when given at the recommended dose to young, healthy women. Despite being rare, this induced psychosis may become more common, especially while becoming more popular as a supportive drug in COVID-19 treatment. While prescribing amantadine clinicians should be aware of the rapid onset of its psychotic complications. Key words: amantadine; intoxication; acute psychosis; COVID-19