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Lack of Association between Monocyte Chemoattractant Protein-1 (MCP-1) Gene Promoter Polymorphism and Behcet’s Disease with and without Ocular Involvement in Iranian Population: A Case–Control Study
- Source :
- Current Eye Research. 47:312-316
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- PURPOSE This case-control study aimed to evaluate the possible association of MCP-1 - 2518A/G genetic polymorphism with Behcet's disease (BD) in the Iranian patients. MATERIALS AND METHODS This study was performed in 135 Behcet's patients (51 ocular and 84 non-ocular) and 79 healthy individuals. Peripheral blood samples were genotyped for MCP-1 - 2518A/G using the PCR-RFLP technique. RESULTS The statistical analysis of MCP-1 - 2518A/G showed no significant differences in genotype/allele frequencies between Behcet's patients and controls. There was no significant association in genotype/allele frequencies between either ocular or non-ocular BD patients and controls. Also, different genotype/allele frequencies between ocular and non-ocular BD were not statistically significant. CONCLUSIONS In this study, with a threshold P-value of 0.05 and an estimated power of 0.81 to detect a significant association (odds ratio ≥1.2), we did not observe any association of this variant with Behcet's disease.
- Subjects :
- medicine.medical_specialty
Genotype
Behcet's disease
Disease
Iran
Polymorphism, Single Nucleotide
Gastroenterology
Cellular and Molecular Neuroscience
Gene Frequency
Polymorphism (computer science)
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Allele frequency
Chemokine CCL2
business.industry
Behcet Syndrome
Case-control study
Promoter
Odds ratio
medicine.disease
eye diseases
Sensory Systems
Ophthalmology
Case-Control Studies
business
Subjects
Details
- ISSN :
- 14602202 and 02713683
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Current Eye Research
- Accession number :
- edsair.doi.dedup.....30aa6b2ff491af9cbacd3b426b2a3065