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Therapeutic properties of Punica granatum L (pomegranate) and its applications in lungābased diseases: A detailed review
- Source :
- Journal of Food Biochemistry. 45
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Respiratory diseases are the prime cause of death and disability worldwide. The majority of lung-based diseases are resistant to treatment. Hence, research on unique drugs/compounds with a more efficient and minimum side effect for treating lung diseases is urgent. Punica granatum L (pomegranate) fruit has been used in the prevention and treatment of various respiratory disorders in recent times. In vivo and in vitro studies have demonstrated that pomegranate fruit, as well as its juice, extract, peel powder, and oil, exert anti-proliferative, anti-oxidant, anti-microbial, anti-inflammatory, anti-cancer, and anti-tumorigenic properties by attenuating various respiratory conditions such as asthma, lung fibrosis, lung cancer, chronic obstructive pulmonary disease (COPD), and alveolar inflammation via modulating various signaling pathways. The current review summarizes the potential properties and medical benefits of pomegranate against different lung-based diseases, also highlighting its possible role in the lung fibrinolytic system. The available data suggest that pomegranate is effective in controlling the disease progressions and could be a potential therapeutic target benefiting human health status. Furthermore, this review also outlines the preclinical and clinical studies highlighting the role of pomegranate in lung diseases further evoking future studies to investigate the effect of intake of this anti-oxidant fruit in larger and well-defined human clinical trials. PRACTICAL APPLICATIONS: This review outlines the putative pharmacologic benefits of P. granatum L (pomegranate) in treating various chronic lung-based diseases such as lung cancer, COPD, ARDS, asthma, lung fibrosis, and cystic fibrosis. This review also highlights the possible inhibitory role of P. granatum L (pomegranate) in the lung fibrinolytic system triggering the fibrinolytic markers. This review summarizes the preclinical and clinical studies using in vitro, in vivo, and human models highlighting the potential role of P. granatum L (pomegranate) in lung diseases. This review evokes future research to investigate the effect of intake of pomegranate fruit in well-defined human clinical trials.
- Subjects :
- Lung Diseases
ARDS
030309 nutrition & dietetics
Biophysics
Disease
Pharmacology
Cystic fibrosis
Pomegranate
03 medical and health sciences
0404 agricultural biotechnology
medicine
Humans
Lung cancer
Lung
0303 health sciences
COPD
biology
Plant Extracts
business.industry
04 agricultural and veterinary sciences
Cell Biology
biology.organism_classification
medicine.disease
040401 food science
respiratory tract diseases
Clinical trial
medicine.anatomical_structure
Fruit
Punica
business
Food Science
Subjects
Details
- ISSN :
- 17454514 and 01458884
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi.dedup.....30b66ddb1a306fbdc83a2e69f3ae2a49