Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl

Authors :: Dawayland O. Cobb
Metrecia L. Terrell
Karen N. Conneely
Michele Marcus
Sarah W. Curtis
Varun Kilaru
M. Elizabeth Marder
Dana B. Barr
Sabrina A. Gerkowicz
Alicia K. Smith
Carmen J. Marsit
Source :: Epigenomics
Publication Year :: 2020
Publisher :: Future Medicine Ltd, 2020.
Abstract: Aim: Michigan residents were exposed to polybrominated biphenyls (PBBs) when it was accidentally added to the food supply. Highly exposed individuals report sex-specific health problems, but the underlying biological mechanism behind these different health risks is not known. Materials and methods: DNA methylation in blood from 381 women and 277 men with PBB exposure was analyzed with the MethylationEPIC BeadChip. Results: 675 CpGs were associated with PBBs levels in males, while only 17 CpGs were associated in females (false discovery rate

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