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Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation
Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation
- Source :
- PLoS ONE, Vol 9, Iss 3, p e93478 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically associated with Kaposi's sarcoma (KS), the most common AIDS-related malignancy. KSHV vIL-6 promotes KS development, but the exact mechanisms remain unclear. Here, we reported that KSHV vIL-6 enhanced the expression of DNA methyltransferase 1 (DNMT1) in endothelial cells,increased the global genomic DNA methylation, and promoted cell proliferation and migration. And this effect could be blocked by the DNA methyltransferase inhibitor, 5-azadeoxycytidine. We also showed that vIL-6 induced up-regulation of DNMT1 was dependent on STAT3 activation. Therefore, the present study suggests that vIL-6 plays a role in KS tumorigenesis partly by activating DNMT1 and inducing aberrant DNA methylation, and it might be a potential target for KS therapy.
- Subjects :
- DNA Methyltransferase Inhibitor
lcsh:Medicine
Pathogenesis
Pathology and Laboratory Medicine
medicine.disease_cause
Biochemistry
Epithelium
Epigenesis, Genetic
Kaposi Sarcoma
Cell Movement
Molecular Cell Biology
Medicine and Health Sciences
DNA (Cytosine-5-)-Methyltransferases
lcsh:Science
Multidisciplinary
Sarcomas
virus diseases
Methylation
Enzymes
Infectious Diseases
Oncology
Host-Pathogen Interactions
Herpesvirus 8, Human
DNA methylation
Azacitidine
Epigenetics
Anatomy
Cellular Types
DNA modification
Research Article
Signal Transduction
DNA (Cytosine-5-)-Methyltransferase 1
STAT3 Transcription Factor
Antimetabolites, Antineoplastic
Biology
Decitabine
Microbiology
DNA methyltransferase
Cell Line
Viral Proteins
Virology
Genetics
medicine
Humans
Kaposi's sarcoma-associated herpesvirus
Cell Proliferation
Biology and life sciences
Interleukin-6
Cell growth
lcsh:R
Endothelial Cells
Cancers and Neoplasms
Epithelial Cells
DNA
Cell Biology
DNA Methylation
Biological Tissue
Viruses and Cancer
Enzymology
Cancer research
DNMT1
lcsh:Q
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....30d7417747f33098ada7de695af2900b