Back to Search
Start Over
Frequency of ventilator circuit changes to prevent ventilator‐associated pneumonia in neonates and children—A systematic review and meta‐analysis
Frequency of ventilator circuit changes to prevent ventilator‐associated pneumonia in neonates and children—A systematic review and meta‐analysis
- Source :
- Pediatric Pulmonology. 56:1357-1365
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- OBJECTIVE To assess the effect of different frequencies of ventilator circuit changes in neonates and children through a systematic review and meta-analysis. INTERVENTIONS (1) "No routine change of ventilator circuit (unless visibly soiled)" versus "routine change at any fixed interval"; (2) routine change of circuit at "less frequent" versus "more frequent" intervals. OUTCOMES Primary outcomes were VAP rate (number of VAP episodes per 1000 ventilator-days) and all-cause mortality before discharge. METHODS MEDLINE, CENTRAL, EMBASE, and CINAHL were systematically searched from inception till November 3, 2020. Two authors assessed trial eligibility and risk of bias, and independently extracted data. Data were synthesized using fixed effects model. GRADE was used to assess certainty of evidence (CoE). RESULTS We identified six studies enrolling 768 participants evaluating circuit changes at two fixed intervals. Meta-analysis of studies on circuit changes "once in less than 7 days" versus "once weekly" showed no difference in VAP rate (risk ratio: 0.83 [0.38-1.81]; one randomized controlled trial (RCT) and 0.94 [0.49-1.81]; two before-after studies) or mortality before discharge (0.67 [0.34-1.3]; one RCT and 1.01 [0.63-1.64]; two before-after studies). CoE was very low. Less frequent circuit changes reduced health-care costs. No study evaluating "circuit changes only when visibly soiled" versus "circuit changes at a fixed interval" was identified. CONCLUSION There is no evidence to suggest that ventilator circuits can be safely left unchanged until visibly soiled in neonates and children. Extending circuit changes interval to "once weekly" may not increase VAP rate (CoE-very low) and reduces healthcare costs.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Ventilator circuit
Ventilators, Mechanical
business.industry
Infant, Newborn
Ventilator-associated pneumonia
MEDLINE
Pneumonia, Ventilator-Associated
Fixed effects model
medicine.disease
law.invention
Randomized controlled trial
law
Meta-analysis
Relative risk
Pediatrics, Perinatology and Child Health
Emergency medicine
medicine
Humans
Fixed interval
sense organs
Child
business
Subjects
Details
- ISSN :
- 10990496 and 87556863
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Pediatric Pulmonology
- Accession number :
- edsair.doi.dedup.....30de56cc528e592ab80731bead70ccee
- Full Text :
- https://doi.org/10.1002/ppul.25345