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Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains
Genetic correlational analysis reveals no association between MPP+ and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains
- Source :
- Neurotoxicol Teratol
- Publication Year :
- 2014
-
Abstract
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a pro-neurotoxicant that must be metabolized to 1-methyl-4-phenylpyridinium (MPP + ) and taken up into striatal dopaminergic neurons to produce neurodegeneration. Recently, we showed wide genetic variability in MPTP-associated neuronal damage in a panel of recombinant inbred mouse strains. Here we examined the amount of MPP + produced in the striatum in the same strains of inbred BXD mice. This allowed us to determine if the differences in the dopaminergic neurotoxicity and associated astrogliosis among the BXD mouse strains were due to differential metabolism of MPTP to MPP + . Using the same BXD mouse strains examined previously (Jones et al., 2013) we found that the extent of the striatal damage produced following MPTP treatment is not correlated quantitatively with the production of MPP + in the striatum. Our findings also extend those of others regarding strain differences in MPTP-induced dopaminergic neurotoxicity. Importantly, our finding suggests that additional factors influence the neurodegenerative response other than the presence and amount of the toxicant at the target site.
- Subjects :
- Male
medicine.medical_specialty
Dopamine
Mice, Inbred Strains
Striatum
Biology
Toxicology
Article
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Mice
Developmental Neuroscience
Species Specificity
Internal medicine
medicine
Animals
Correlational analysis
Gliosis
MPTP
Neurodegeneration
Dopaminergic
Neurotoxicity
MPTP Poisoning
medicine.disease
Astrogliosis
Neostriatum
Endocrinology
chemistry
nervous system
Neuroscience
Toxicant
Subjects
Details
- ISSN :
- 18729738
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Neurotoxicology and teratology
- Accession number :
- edsair.doi.dedup.....30f98e6446ce9d7c46d0b59d9f9537ae