Back to Search
Start Over
Energy expenditure during synthetic surfactant replacement therapy for neonatal respiratory distress syndrome
- Source :
- The Journal of Pediatrics. 120:S29-S33
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- Little information is available on the energy expenditure of infants with increased work of breathing from respiratory distress syndrome (RDS). A study was carried out to determine whether surfactant replacement therapy modifies respiratory gas exchange in newborn infants with RDS and an arterial-alveolar oxygen tension ratio of less than 0.22. In a double-blind, placebo-controlled, rescue trial, infants received either two 5 ml/kg doses of a synthetic surfactant, Exosurf Neonatal, or air placebo. Of 23 infants ventilated for RDS, 11 were randomly assigned to receive air and 12 to receive surfactant. Oxygen consumption, carbon dioxide production, respiratory quotient, and metabolic rate were measured by computerized, closed-circuit, indirect calorimetry. Concomitantly, transcutaneous oxygen and carbon dioxide tension were continuously recorded. Oxygen consumption and carbon dioxide production remained constant during the period infants received surfactant. In patients randomly assigned to surfactant, a decrease in respiratory quotient was observed after the first (p less than 0.025) but not the second dose. This decrease was possibly related to a change in substrate utilization. The improved clinical outcomes reported among infants receiving surfactant were not accompanied by changes in energy expenditure.
- Subjects :
- Neonatal respiratory distress syndrome
Phosphorylcholine
Placebo
Polyethylene Glycols
Work of breathing
chemistry.chemical_compound
Pulmonary surfactant
medicine
Humans
Respiratory Distress Syndrome, Newborn
Respiratory distress
business.industry
Infant, Newborn
Calorimetry, Indirect
Pulmonary Surfactants
Infant, Low Birth Weight
medicine.disease
Oxygen tension
Respiratory quotient
Drug Combinations
chemistry
Anesthesia
Pediatrics, Perinatology and Child Health
Carbon dioxide
Fatty Alcohols
Energy Metabolism
business
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....310219fc9d27521fdcd6a0f963ecd4d3