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The association between C-159T polymorphism in CD14 gene and susceptibility to tuberculosis: a meta-analysis
- Source :
- Molecular biology reports. 41(11)
- Publication Year :
- 2013
-
Abstract
- The association between CD14 gene C-159T polymorphism and tuberculosis (TB) susceptibility remains inconclusive. To derive a more precise estimation of the correlation, we performed a meta-analysis summarize the possible at a systematic manner. PubMed, HighWire and ScienceDirect databases covering all papers (up to November 2012) were searched. Statistical analyses were conducted by Rev-Man and STATA. Random- and fixed-effect models were used to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs), based on between-study heterogeneity. Eight published case-control studies investigating the relationship between C-159T polymorphism in CD14 gene and TB susceptibility were included. Results showed that individuals with T allele have an increased risk of TB compared with those with C allele (OR (95% CI) was 1.52 (1.11, 2.08) for TT vs. TC + CC, P < 0.001; 1.27 (1.01, 1.61) for T vs. C, P = 0.04). When stratified by ethnicity, variant TT homozygote carriers had an 86% increased risk of TB in Asians (OR (95% CI) was 1.86 (1.57, 2.20) for TT vs. TC + CC, P < 0.001), but not in Caucasians (OR (95% CI) was TT vs. TC + CC: OR = 0.78, 95% CI = 0.51-1.21, P = 0.61). This meta-analysis suggests that C-159T polymorphism in CD14 gene is associated with increased risk of TB, especially in Asians, but not in Caucasians.
- Subjects :
- medicine.medical_specialty
Tuberculosis
CD14
Lipopolysaccharide Receptors
Bioinformatics
Gastroenterology
Polymorphism, Single Nucleotide
White People
Asian People
Internal medicine
Genetics
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
Allele
Molecular Biology
Gene
business.industry
General Medicine
Odds ratio
medicine.disease
Confidence interval
Increased risk
Meta-analysis
business
Subjects
Details
- ISSN :
- 15734978
- Volume :
- 41
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecular biology reports
- Accession number :
- edsair.doi.dedup.....310683c16477f9a805b0927fa618b16d