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Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body?
- Source :
- Brain Research. 872:199-203
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded approximately 20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2-10 microM) application, and inhibited by the 5-HT receptor blocker, ketanserin (50-100 microM). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms.
- Subjects :
- Periodicity
Serotonin
medicine.medical_specialty
Patch-Clamp Techniques
Ketanserin
Chemoreceptor
Action Potentials
Endogeny
Biology
Internal medicine
Paracrine Communication
medicine
Animals
Autocrine signalling
Receptor
Molecular Biology
Cells, Cultured
5-HT receptor
Carotid Body
General Neuroscience
Cell Hypoxia
Chemoreceptor Cells
Rats
Autocrine Communication
Electrophysiology
Endocrinology
medicine.anatomical_structure
Carotid body
Serotonin Antagonists
Neurology (clinical)
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 872
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....3109b8a515e152fe9006b82acce4e10f