Back to Search Start Over

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Authors :
Rustam Al-Shahi Salman
David P Minks
Dipayan Mitra
Mark A Rodrigues
Priya Bhatnagar
Johann C du Plessis
Yogish Joshi
Martin S Dennis
Gordon D Murray
David E Newby
Peter A G Sandercock
Nikola Sprigg
Jacqueline Stephen
Cathie L M Sudlow
David J Werring
William N Whiteley
Joanna M Wardlaw
Philip M White
Colin Baigent
Daniel Lasserson
Frank Sullivan
Johanna Carrie
Javier Rojas
Shannon Amoils
John Bamford
Jane Armitage
Gabriel Rinkel
Gordon Lowe
Jonathan Emberson
Karen Innes
Lynn Dinsmore
Jonathan Drever
Carol Williams
David Perry
Connor McGill
David Buchanan
Allan Walker
Aidan Hutchison
Christopher Matthews
Ruth Fraser
Aileen McGrath
Ann Deary
Rosemary Anderson
Pauli Walker
Christian Hansen
Richard Parker
Aryelly Rodriguez
Malcolm Macleod
Thomas Gattringer
Jeb Palmer
Eleni Sakka
Jennifer Adil-Smith
David Minks
Johannes du Plessis
Christine Lerpiniere
Richard O'Brien
Seona Burgess
Gillian Mead
Ruth Paulton
Fergus Doubal
Katrina McCormick
Neil Hunter
Pat Taylor
Ruwan Parakramawansha
Jack Perry
Gordon Blair
Allan MacRaild
Adrian Parry-Jones
Mary Johnes
Stephanie Lee
Kelly Marie Shaw
Ilse Burger
Martin Punter
Andrea Ingham
Jane Perez
Zin Naing
Jordi Morell
Tracy Marsden
Andrea Hall
Sally Marshall
Louise Harrison
Rowilson Jarapa
Edith Wood
Victoria O'Loughlin
David Cohen
Silvie Davies
Kelechi Njoku
Mushiya Mpelembue
Laura Burgess
Radim Licenik
Mmua Ngwako
Nabeela Nisar
Rangah Niranchanan
Tatjana Roganova
Rajaram Bathula
Joseph Devine
Anette David
Anne Oshodi
Fenglin Guo
Emmanuelle Owoyele
Varthi Sukdeo
Robert Ballantine
Mudhar Abbdul-saheb
Angela Chamberlain
Aberami Chandrakumar
Philip Poku
Kirsty Harkness
Catrin Blank
Emma Richards
Ali Ali
Faith Kibutu
Olesia Balitska
Kathryn Birchall
Pauline Bayliss
Clare Doyle
Kathy Stocks
Arshad Majis
Jo Howe
Christine Kamara
Luke Barron
Ahmad Maatouk
Ralf Lindert
Katy Dakin
Jessica Redgrave
Biju Bhaskaran
Isam Salih
Debs Kelly
Susan Szabo
Dawn Tomlin
Helen Bearne
Jean Buxton
Pauline Fitzell
Georgina Ayres
Afaq Saulat
Kathleen Horan
Joanne Garfield-Smith
Harbens Bhakri
Paul Guyler
Devesh Sinha
Thayalini Loganathan
Amber Siddiqui
Anwer Siddiqui
Lucy Coward
Swapna Kunhunny
Sharon Tysoe
Rajalakshmi Orath Prabakaran
Shyam Kelavkar
Sindhu Rashmi
David Ngo
Kheng Xiong Ng
Nisha Menon
Sweni Shah
Mark Barber
Derek Esson
Fiona Brodie
Talat Anjum
Mushtaq Wani
Manju Krishnan
Leanne Quinn
Jayne Spencer
Terry Jones
Helen Thompson-Jones
Lynne Dacey
Srikanth Chenna
Sharon Storton
Sarah Thomas
Teresa Beaty
Shelley Treadwell
Caroline Davies
Susan Tucker
Lynda Connor
Peter Slade
Glyn Gainard
Girish Muddegowda
Ranjan Sanyal
Alda Remegoso
Nenette Abano
Chelsea Causley
Racquel Carpio
Stephanie Stevens
Adrian Butler
Resti Varquez
Hayley Denic
Francis Alipio
Andrew Moores
Adrian Barry
Holly Maguire
Jeanette Grocott
Kay Finney
Sue Lyjko
Christine Roffe
Joanne Hiden
Phillip Ferdinand
Vera Cvoro
Khalil Ullah
Nicola Chapman
Mandy Couser
Susan Pound
Sean Mcauley
Senthil Raghunathan
Faye Shelton
Amanda Hedstrom
Margi Godfrey
Diane Havard
Amanda Buck
Kailash Krishnan
Nicola Gilzeane
Jack Roffe
Judith Clarke
Katherine Whittamore
Saima Sheikh
Rekha Keshvara
Carla Jordan
Benjamin Jackson
Gwendoline Wilkes
Jason Appleton
Zhe Law
Oliver Matias
Evangelos Vasileiadis
Cathy Mason
Anthea Parry
Geraldine Landers
Melinda Holden
Basaam Aweid
Khalid Rashed
Linda Balian
Carinna Vickers
Elizabeth Keeling
Sarah Board
Joanna Allison
Clare Buckley
Barbara Williams-Yesson
Joanne Board
Tressy Pitt-Kerby
Alfonso Tanate
Diane Wood
Manohar Kini
Dinesh Chadha
Deborah Walstow
Rosanna Fong
Robert Luder
Tolu Adesina
Jill Gallagher
Hayley Bridger
Elodie Murali
Maneesh Bhargava
Chloe van Someren
Frances Harrington
Abhijit Mate
Ali James
Gillian Courtauld
Christine Schofield
Katja Adie
Linda Lucas
Kirsty Bond
Bev Maund
Sam Ellis
Paul Mudd
Martin James
Samantha Keenan
Angela Bowring
Julie Cageao
Hayley Kingwell
Caroline Roughan
Anthony Hemsley
Jane Sword
David Strain
Keniesha Miller
Anita Goff
Karin Gupwell
Kevin Thorpe
Hedley Emsley
Shuja Punekar
Alison McLoughlin
Sulaiman Sultan
Bindu Gregory
Sonia Raj
Donna Doyle
Keith Muir
Wilma Smith
Angela Welch
Fiona Moreton
Bharath Kumar Cheripelli
Salwa El Tawil
Dheeraj Kalladka
Xuya Huang
Nicola Day
Sankaranarayanan Ramachandran
Caroline Crosbie
Jennifer Elliot
Tony Rudd
Katherine Marks
Ajay Bhalla
Jonathan Birns
Sagal Kullane
Nic Weir
Christopher Allen
Vanessa Pressly
Pam Crawford
Emma Battersby-Wood
Alex Blades
Shuna Egerton
Ashleigh Walters
Sue Evans
James Richard Marigold
Fiona Smith
Gabriella Howard
Imogen Gartrell
Simon Smith
Robyn Creeden
Chloe Cox
Cherish Boxall
Jonathan Hewitt
Claire Nott
Procter Sarah
Jessica Whiteman
Steve Buckle
Rebecca Wallace
Rina Mardania
Jane Gray
Claire Triscott
Anand Nair
Jill Greig
Pratap Rana
Matthew Robinson
Mohammad Irfan Alam
David Werring
Duncan Wilson
Caroline Watchurst
Maria Brezitski
Luci Crook
Ifan Jones
Azra Banaras
Krishna Patel
Renuka Erande
Caroline Hogan
Isabel Hostettler
Amy Ashton
Shez Feerick
Nina Francia
Nnebuife Oji
Emma Elliott
Talal Al-Mayhani
Martin Dennis
Cathie Sudlow
William Whiteley
Dipankar Dutta
Pauline Brown
Deborah Ward
Fiona Davis
Jennifer Turfrey
Chloe Hughes
Kayleigh Collins
Rehana Bakawala
Susan O'Connell
Jon Glass
David Broughton
Dinesh Tryambake
Lynn Dixon
Kath Chapman
Andrew Young
Adrian Bergin
Andrew Sigsworth
Aravind Manoj
Glyn Fletcher
Paula Lopez
Penelope Cox
Mark Wilkinson
Paul Fitzsimmons
Nikhil Sharma
James Choulerton
Denise Button
Lindsey Dow
Lukuman Gbadamoshi
Joanne Avis
Barbara Madigan
Stephanie McCann
Louise Shaw
Deborah Howcroft
Suzanne Lucas
Andrew Stone
Gillian Cluckie
Caroline Lovelock
Brian Clarke
Neha Chopra
Natasha Clarke
Bhavini Patel
Kate Kennedy
Rebecca Williams
Adrian Blight
Joanna O'Reilly
Chukwuka Orefo
Nilofer Dayal
Rita Ghatala
Temi Adedoyin
Fran Watson
Sarah Trippier
Lillian Choy
Barry Moynihan
Usman Khan
Val Jones
Naomi Jeyaraj
Lourda Kerin
Kamy Thavanesan
Divya Tiwari
Chantel Cox
Anja Ljubez
Laura Tucker
Arshi Iqbal
Caroline Bagnall
Marketa Keltos
Josh Roberts
Becky Jupp
Catherine Ovington
Emily Rogers
Owen David
Jo Bell
Barbara Longland
Gail Hann
Martin Cooper
Mohammad Nasar
Anoja Rajapakse
Inez Wynter
Ijaz Anwar
Helen Skinner
Tarn Nozedar
Damian McArdle
Balakrishna Kumar
Susan Crawford
Arunkumar Annamalai
Alex Ramshaw
Clare Holmes
Sarah Caine
Mairead Osborn
Emily Dodd
Peter Murphy
Nicola Devitt
Pauline Baker
Amy Steele
Lucy Belle Guthrie
Samantha Clarke
Ahamad Hassan
Dean Waugh
Emelda Veraque
Linetty Makawa
Mary Kambafwile
Marc Randall
Vasileios Papavasileiou
Claire Cullen
Jenny Peters
Hlaing Thant
Tanya Ingram
Mellor Zoe
Ramesh Durairaj
Melanie Harrison
Sarah Stevenson
Daniela Shackcloth
Jordan Ewing
Victoria Sutton
Mark McCarron
Jacqueline McKee
Mandy Doherty
Ferghal McVerry
Caroline Blair
Mary MacLeod
Janice Irvine
Heather Gow
Jacqueline Furnace
Anu Joyson
Baljit Jagpal
Sarah Ross
Katrina Klaasen
Sandra Nelson
Rebecca Clarke
Nichola Crouch
Beverly MacLennan
Vicky Taylor
Daniel Epstein
Avani Shukla
Vinodh Krishnamurthy
Paul Nicholas
Sammie Qureshi
Adam Webber
Justin Penge
Hawraman Ramadan
Stuart Maguire
Chris Patterson
Ruth Bellfield
Brigid Hairsine
Kelvin Stewart
Michaela Hooley
Outi Quinn
Bella Richard
Sally Moseley
Mandy Edwards
Heidi Lawson
Michelle Tayler
Yogish Pai
Mahesh Dhakal
Bernard Esisi
Sofia Dima
Gemma Marie Smith
Mark Garside
Muhammad Naeem
Vidya Baliga
Gill Rogers
Ellen Brown
David Bruce
Rachel Hayman
Susan Clayton
Ed Gamble
Rebecca Grue
Bethan Charles
Adam Hague
Sujata Blane
Caroline Lambert
Afnan Chaudhry
Thomas Harrison
Kari Saastamoinen
Dionne Hove
Laura Howaniec
Gemma Grimwood
Ozlem Redjep
Fiona Humphries
Lucia Argandona
Larissa Cuenoud
Esther Erumere
Sageet Amlani
Grace Auld
Afraim Salek-Haddadi
Ursula Schulz
James Kennedy
Gary Ford
Philip Mathieson
Ian Reckless
Rachel Teal
Giulia Lenti
George Harston
Eoin O'Brien
Joanne Mcgee
Jennifer Mitchell
Elaine Amis
Dominic Handley
Siobhan Kelly
George Zachariah
Jobbin Francis
Sarah Crisp
Juliana Sesay
Sarah Finlay
Helen Hayhoe
Niamh Hannon
Tom Hughes
Bethan Morse
Henry De Berker
Emma Tallantyre
Ahmed Osman
Susan White
Stefan Schwarz
Benjamin Jelley
Rajendra Yadava
Khalid Azhar
Julie Reddan
Mirriam Sangombe
Samantha Stafford
Ken Fotherby
Debbie Morgan
Farrukh Baig
Karla Jennings-Preece
Donna Butler
Nasar Ahmad
Angela Willberry
Angela Stevens
Baljinder Rai
Prasad Siddegowda
Peter Howard
Lisa Hyatt
Tracey Dobson
David Jarrett
Suheil Ponnambath
Jane Tandy
Yasmin Harrington-Davies
Rebecca Butler
Claire James
Stacey Valentine
Anne Suttling
Peter Langhorne
Gillian Kerr
Fiona Wright
Ruth Graham
Christine McAlpine
Mohammad Shahzad Iqbal
Louise Humphreys
Kath Pasco
Olga Balazikova
Ashraf Nasim
Cassilda Peixoto
Louise Gallagher
Shahrzad Shahmehri
Sandip Ghosh
Elizabeth Barrie
Danielle Gilmour
Margo Henry
Tom Webb
Linda Cowie
Hannah Rudenko
Shanni McDonald
Natasha Schumacher
Susannah Walker
Tracey Cosier
Anna Verrion
Eva Beranova
Audrey Thomson
Marius Venter
Arindam Kar
Sheila Mashate
Kirsten Harvey
Léjeune Gardener
Vinh Nguyen
Omid Halse
Olivia Geraghty
Beth Hazel
Peter Wilding
Victoria Tilley
Tim Cassidy
Beverley McClelland
Maria Bokhari
Timothy England
Mohana Maddula
Richard Donnelly
Paul Findlay
Ashish Macaden
Ian Shread
Charlotte Barr
Azlisham Mohd Nor
Claire Brown
Nicola Persad
Charlotte Eglinton
Marie Weinling
Benjamin Hyams
Alex Shah
John Baker
Anthony Byrne
Caroline McGhee
Amanda Smart
Claire Copeland
Michael Carpenter
Marion Walker
Richard Davey
Ann Needle
Razik Fathima
Gavin Bateman
Prabal Datta
Andrew Stanners
Linda Jackson
Julie Ball
Michelle Davis
Natalie Atkinson
Michelle Fawcett
Teresa Thompson
Helen Guy
Valerie Hogg
Carole Hays
Stephen Woodward
Mohammad Haque
Eluzai Hakim
Stuart Symonds
Mehran Maanoosi
Jane Herman
Toby Black
Skelton Miriam
Caroline Clarke
Alpha Anthony
Michele Tribbeck
Julie Cronin
Denise Mead
Ruth Fennelly
James McIlmoyle
Christina Dickinson
Carol Jeffs
Sajjad Anwar
Joanne Howard
Kirsty Jones
Saikat Dhar
Caroline Clay
Muhammad Siddiq
Simone Ivatts
Yolanda Baird
Moore Sally
Isobel Amey
Sophie Newton
Lisa Clayton-Evans
Indra Chadbourn
Rayessa Rayessa
Charde Naylor
Alicia Rodgers
Lisa Wilson
Sarah Wilson
Emma Clarkson
Ruth Davies
Paula Owings
Graeme Sangster
Valerie Gott
Victoria Little
Pauline Weir
Suja Cherian
Deepa Jose
Helen Moroney
Susan Downham
Angela Dodd
Venetia Vettimootal Johnson
Laura Codd
Naomi Robinson
Ashraf Ahmed
Mo Albazzaz
Sharon Johnson
Carol Denniss
Mishell Cunningham
Tajammal Zahoor
Timothy Webster
Sandra Leason
Syed Haider
Kausic Chatterjee
Arumugam Nallasivan
Charlotte Perkins
Samantha Seagrave
Colin Jenkins
Fiona Price
Claire Hughes
Lily Mercer
Malik Hussain
Sarah Brown
Miriam Harvey
Jane Homan
Mohammad Khan
Robert Whiting
Leanne Foote
Nicholas Hunt
Helen Durman
Lucy Brotherton
Jayne Foot
Corinne Pawley
Eliza Foster
Alison Whitcher
Kneale Metcalf
Jenny Jagger
Susan McDonald
Kelly Waterfield
Patrick Sutton
Naval Shinh
Ajmal Anversha
Garth Ravenhill
Richard Greenwood
Janak Saada
Alison Wiltshire
Rebekah Perfitt
Sreeman Andole
Naveen Gadapa
Karen Dunne
Magdalini Krommyda
Evelyne Burssens
Sam King
Catherine Plewa
Nigel Smyth
Jenny Wilson
Elio Giallombardo
Lucy Sykes
Pradeep Kumar
James Barker
Isabel Huggett
Linda Dunn
Charlotte Culmsee
Philip Thomas
Min Myint
Helen Brew
Nikhil Majmudar
Janice OConnell
George Bunea
Charlotte Fox
Diane Gulliver
Andrew Smith
Betty Mokoena
Naweed Sattar
Ramesh Krishnamurthy
Emily Osborne
David Wilson
Belinda Wroath
Kevin Dynan
Michael Power
Susan Thompson
Victoria Adell
Enoch Orugun
Una Poultney
Rachel Glover
Hannah Crowther
Sarah Thornthwaite
Ivan Wiggam
Aine Wallace
Enda Kerr
Ailsa Fulton
Annemarie Hunter
Suzanne Tauro
Sarah Cuddy
David Mangion
Anne Hardwick
Skarlet Markova
Tara Lawrence
Carmen Constantin
Jo Fletcher
Isobel Thomas
Kerry Pettitt
Lakshmanan Sekaran
Margaret Tate
Kiranjit Bharaj
Rohan Simon
Frances Justin
Sakthivel Sethuraman
Duke Phiri
Niaz Mohammed
Meena Chauhan
Khaled Elfandi
Uzma Khan
David Eveson
Amit Mistri
Lisa Manning
Shagufta Khan
Champa Patel
Mohammed Moqsith
Saira Sattar
Man Yee Lam
Kashif Musarrat
Claire Stephens
Latheef Kalathil
Richard Miller
Maqsud Salehin
Nikki Gautam
Duncan Bailey
Kelly Amor
Julie Meir
Anne Nicolson
Javed Imam
Lisa Wood
Julie White
Mahmud Sajid
George Ghaly
Margaret Ball
Rachel Gascoyne
Harald Proeschel
Simon Sharpe
Sarah Horton
Emily Beaves
Stephanie Jones
Brigitte Yip
Murdina Bell
Linda MacLiver
Brian MacInnes
Don Sims
Jennifer Hurley
Mark Willmot
Claire Sutton
Edward Littleton
Susan Maiden
Rachael Jones
James Cunningham
Carole Green
Michelle Bates
Raj Shekhar
Ellie Gilham
Iman Ahmed
Rachel Crown
Tracy Fuller
Neetish Goorah
Angela Bell
Christine Kelly
Arun Singh
Jamie Walford
Benjamin Tomlinson
Farzana Patel
Stephen Duberley
Ingrid Kane
Chakravarthi Rajkumar
Jane Gaylard
Joanna Breeds
Nicola Gainsborough
Alexandra Pitt-Ford
Emma Barbon
Laura Latter
Philip Thompson
Simon Hervey
Shrivakumar Krishnamoorthy
Joseph Vassallo
Deborah Walter
Helen Cochrane
Meena Srinivasan
Robert Campbell
Denise Donaldson
Nichola Motherwell
Frances Hurford
Indranil Mukherjee
Antony Kenton
Sheila Nyabadza
Irene Martin
Benjamin Hunt
Hardi Hassan
Sarah O'Toole
Bander Dallol
Janet Putterill
Ratneshwari Jha
Rachel Gallifent
Puneet Kakar
Aparna Pusalkar
kelly Chan
Puneet Dangri
Hannah Beadle
Angela Cook
Karen Crabtree
Santhosh Subramonian
Peter Owusu-Agyei
Natalie Temple
Nicola Butterworth-Cowin
Suzanne Ragab
Kerstin Knops
Emma Jinks
Christine Dickson
Laura Gleave
Judith Dube
Jacqui Leggett
Tatiana Garcia
Sissy Ispoglou
Rachel Evans
Sandeep Ankolekar
Anne Hayes
Hlaing Ni
Bithi Rahman
Josette Milligan
Carol Graham
Josin Jose
Breffni Keegan
Jim Kelly
Richard Dewar
James White
Kelly Thomas
Rajkumar, C
University of St Andrews. School of Medicine
University of St Andrews. Sir James Mackenzie Institute for Early Diagnosis
University of St Andrews. Population and Behavioural Science Division
University of St Andrews. Pure Mathematics
University of St Andrews. School of Psychology and Neuroscience
University of St Andrews. School of Biology
Source :
BASE-Bielefeld Academic Search Engine, Al-Shahi Salman, R, Minks, D P, Mitra, D, Rodrigues, M A, Bhatnagar, P, du Plessis, J C, Joshi, Y, Dennis, M S, Murray, G D, Newby, D E, Sandercock, P A G, Sprigg, N, Stephen, J, Sudlow, C L M, Werring, D J, Whiteley, W N, Wardlaw, J M, White, P M 2019, ' Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : Subgroup analyses of the RESTART randomised, open-label trial ', Lancet Neurology, vol. 18, no. 7, pp. 643-652 . https://doi.org/10.1016/S1474-4422(19)30184-X, The Lancet Neurology, 18(7), 643. Lancet Publishing Group, RESTART collaboration & Njoku, K 2019, ' Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial ', The Lancet. Neurology, vol. 18, no. 7, pp. 643-652 . https://doi.org/10.1016/S1474-4422(19)30184-X
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Background: Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy.Methods: RESTART was a prospective, randomised, open-label, blinded-endpoint, parallel-group trial at 122 hospitals in the UK that assessed whether starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. For this prespecified subgroup analysis, consultant neuroradiologists masked to treatment allocation reviewed brain CT or MRI scans performed before randomisation to confirm participant eligibility and rate features of the intracerebral haemorrhage and surrounding brain. We followed participants for primary (recurrent symptomatic intracerebral haemorrhage) and secondary (ischaemic stroke) outcomes for up to 5 years (reported elsewhere). For this report, we analysed eligible participants with intracerebral haemorrhage according to their treatment allocation in primary subgroup analyses of cerebral microbleeds on MRI and in exploratory subgroup analyses of other features on CT or MRI. The trial is registered with the ISRCTN registry, number ISRCTN71907627.Findings: Between May 22, 2013, and May 31, 2018, 537 participants were enrolled, of whom 525 (98%) had intracerebral haemorrhage: 507 (97%) were diagnosed on CT (252 assigned to start antiplatelet therapy and 255 assigned to avoid antiplatelet therapy, of whom one withdrew and was not analysed) and 254 (48%) underwent the required brain MRI protocol (122 in the start antiplatelet therapy group and 132 in the avoid antiplatelet therapy group). There were no clinically or statistically significant hazards of antiplatelet therapy on recurrent intracerebral haemorrhage in primary subgroup analyses of cerebral microbleed presence (2 or more) versus absence (0 or 1) (adjusted hazard ratio [HR] 0·30 [95% CI 0·08–1·13] vs 0·77 [0·13–4·61]; pinteraction=0·41), cerebral microbleed number 0–1 versus 2–4 versus 5 or more (HR 0·77 [0·13–4·62] vs 0·32 [0·03–3·66] vs 0·33 [0·07–1·60]; pinteraction=0·75), or cerebral microbleed strictly lobar versus other location (HR 0·52 [0·004–6·79] vs 0·37 [0·09–1·28]; pinteraction=0·85). There was no evidence of heterogeneity in the effects of antiplatelet therapy in any exploratory subgroup analyses (all pinteraction>0·05).Interpretation: Our findings exclude all but a very modest harmful effect of antiplatelet therapy on recurrent intracerebral haemorrhage in the presence of cerebral microbleeds. Further randomised trials are needed to replicate these findings and investigate them with greater precision.Funding: British Heart Foundation.

Details

Language :
English
ISSN :
14744422
Database :
OpenAIRE
Journal :
BASE-Bielefeld Academic Search Engine, Al-Shahi Salman, R, Minks, D P, Mitra, D, Rodrigues, M A, Bhatnagar, P, du Plessis, J C, Joshi, Y, Dennis, M S, Murray, G D, Newby, D E, Sandercock, P A G, Sprigg, N, Stephen, J, Sudlow, C L M, Werring, D J, Whiteley, W N, Wardlaw, J M, White, P M 2019, ' Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : Subgroup analyses of the RESTART randomised, open-label trial ', Lancet Neurology, vol. 18, no. 7, pp. 643-652 . https://doi.org/10.1016/S1474-4422(19)30184-X, The Lancet Neurology, 18(7), 643. Lancet Publishing Group, RESTART collaboration & Njoku, K 2019, ' Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial ', The Lancet. Neurology, vol. 18, no. 7, pp. 643-652 . https://doi.org/10.1016/S1474-4422(19)30184-X
Accession number :
edsair.doi.dedup.....311b0f3c35002aa7ebe1d944a19a6298
Full Text :
https://doi.org/10.1016/S1474-4422(19)30184-X