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Larger and deeper ventricular lesions using a novel expandable spherical monopolar irrigated radiofrequency ablation catheter
- Source :
- Journal of Cardiovascular Electrophysiology. 30:1644-1651
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- BACKGROUND Radiofrequency (RF) ablation is an established treatment for ventricular tachycardia (VT). However, the inability of current RF catheters to address deep or large substrate may explain most of the clinical failures. OBJECTIVES The aim of this study is to assess the efficacy and safety of ablation in the left ventricle (LV) in sheep using a novel 8-Fr deflectable ablation catheter (Sphere-9; Affera, Inc) with a 9-mm expandable spherical monopolar irrigated RF tip vs a standard RF irrigated catheter (Biosense Webster, Diamond Bar, CA). The impact on tissue was assessed on local bipolar electrograms (from nine uniformly distributed mini surface electrodes and an internal central reference electrode), as well as on direct lesion measurement post mortem. METHODS AND RESULTS Eleven sheep underwent LV endocardial ablation in healthy tissue using the Sphere-9 catheter (n = 6), or a conventional irrigated RF catheter (n = 5). Twenty lesions were created with the Sphere-9 (current limit: 2.7 A; temp. limit: 60°C; irrigation: 30 mL/min; and duration: 60-120 seconds). Local bipolar electrograms at the surface of the catheter disappeared during RF delivery in 17 of 20 (85%) lesions. The mean lesion volume was 1707 ± 771 mm 3 (length: 15.8 ± 3.3 mm; width: 11.6 ± 4.2 mm; and depth: 10.3 ± 2.9 mm). Twenty-five lesions were created with a standard RF irrigated catheter (power control 35 W; irrigation: 30 mL/min; duration: 60 seconds; volume 537 ± 398 mm 3 ; length: 8.2 ± 2.3 mm; width: 5.2 ± 1.8 mm; and depth: 5.5 ± 2.4 mm). The novel spherical RF catheter created significantly larger lesions ( P
- Subjects :
- Cardiac Catheterization
Time Factors
Heart Ventricles
medicine.medical_treatment
Action Potentials
Lesion volume
030204 cardiovascular system & hematology
Ventricular tachycardia
Cardiac Catheters
Lesion
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
medicine
Animals
Humans
030212 general & internal medicine
Therapeutic Irrigation
Sheep, Domestic
business.industry
Equipment Design
Ablation
medicine.disease
Radiofrequency ablation catheter
Catheter
medicine.anatomical_structure
Ventricle
Models, Animal
Catheter Ablation
Female
Irrigated catheter
medicine.symptom
Electrophysiologic Techniques, Cardiac
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Subjects
Details
- ISSN :
- 15408167 and 10453873
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Electrophysiology
- Accession number :
- edsair.doi.dedup.....31289e82a819b50fa6b1b872a463840c