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Inherently chiral dialkyloxy‐calix[4]arene acetic acids as enantiodiscriminating additives for high‐performance liquid chromatography separation of <scp>d</scp> , <scp>l</scp> ‐amino acids
- Source :
- Chirality. 33:722-730
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Inherently chiral dialkyloxy-calix[4]arene acetic acids with asymmetric placement of substituents on the lower rim of the macrocycle were first studied as enantiodiscriminating additives to the mobile phase MeCN/H2 O/HCOOH (75/25/0.02 by volume) in the high-performance liquid chromatography (HPLC) separation of d,l-alanine and d,l-valine on the achiral stationary phase ZORBAX Original CN. The dependence of enantio-binding properties on the position of alkyl groups is demonstrated. The highest resolution (1.65) and enantioselectivity (1.80) were obtained for the 1,2-dipropyloxy-calix[4]arene acetic acid.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Resolution (mass spectrometry)
Organic Chemistry
Stereoisomerism
Acetates
Medicinal chemistry
High-performance liquid chromatography
Catalysis
Analytical Chemistry
Amino acid
Acetic acid
chemistry.chemical_compound
Phenols
chemistry
Stationary phase
Phase (matter)
Drug Discovery
Amino Acids
Calixarenes
Chromatography, High Pressure Liquid
Spectroscopy
Alkyl
Subjects
Details
- ISSN :
- 1520636X and 08990042
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Chirality
- Accession number :
- edsair.doi.dedup.....312984358e6ce29c6a352ded20b7b830