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Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum
- Source :
- Biochemical Pharmacology. 178:114120
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- As a stable environmental contaminant, nonylphenol (NP) has been shown to induce some neurological deficits in the cerebellum, although the underlying mechanism is still unknown. In the present study, we aimed to investigate the effects of perinatal exposure to NP on myelination, an important process essential for the intact cerebellar function, in the offspring cerebellum. Exposure to NP delayed the myelination in the offspring cerebellum during perinatal period. The myelination recovered in the cerebellum of offspring exposed to NP over time, and returned to normal in adulthood. In addition, perinatal exposure to NP reduced mature oligodendrocytes (myelin-forming glial cells) and increased astrocytes in the offspring cerebellum. BMP signaling is believed to negatively regulate oligodendrogliogenesis and myelination. In the present study, BMP4, p-Smad1/5, and ID4, key members of BMP signaling, were increased in the cerebellum of offspring exposed to NP. Taken together, these lines of evidence suggest that the activation of BMP signaling may underlie the decreased oligodendrogliogenesis and increased astrogliogenesis, and the consequent delay of myelination in the cerebellum of offspring perinatally exposed to NP.
- Subjects :
- Male
Smad5 Protein
0301 basic medicine
Cerebellum
medicine.medical_specialty
Delayed myelination
Offspring
Cell Count
Bone Morphogenetic Protein 4
Biology
Biochemistry
Smad1 Protein
03 medical and health sciences
chemistry.chemical_compound
Fetus
0302 clinical medicine
Phenols
Pregnancy
Internal medicine
Bmp signaling
medicine
Animals
Rats, Wistar
Myelin Sheath
Pharmacology
Perinatal Exposure
Cerebellar function
Gene Expression Regulation, Developmental
Environmental Exposure
Oligodendrocyte
Rats
Nonylphenol
Oligodendroglia
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Animals, Newborn
nervous system
chemistry
Astrocytes
Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
Environmental Pollutants
Female
Inhibitor of Differentiation Proteins
Signal Transduction
Subjects
Details
- ISSN :
- 00062952
- Volume :
- 178
- Database :
- OpenAIRE
- Journal :
- Biochemical Pharmacology
- Accession number :
- edsair.doi.dedup.....31309742c955275e07c81dd02688dd75