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The glutathione-related detoxification pathway in the human breast. A highly coordinated system disrupted in the tumour tissues

Authors :
Denyse Bagrel
Nicolas Froment
Thierry Oster
Magali Perquin
Michel Untereiner
Armand Maul
Laboratoire Méthodes Mathématiques pour l'Analyse des Systèmes (MMAS)
Centre National de la Recherche Scientifique (CNRS)-Université Paul Verlaine - Metz (UPVM)
Université Paul Verlaine - Metz (UPVM)-Centre National de la Recherche Scientifique (CNRS)
MAUL, Armand
Source :
Cancer Letters, Cancer Letters, Elsevier, 2000
Publication Year :
2000
Publisher :
HAL CCSD, 2000.

Abstract

Glutathione and the associated enzymes, glutathione S-transferases, peroxidases, and reductase, have been implicated in cancer chemoresistance. This pathway was investigated in paired cancerous and peritumoral breast samples from 41 women. The tumours exhibited a higher redox status as deduced from increased transferase, peroxidase, and reductase activities and from higher total and reduced glutathione contents. Several components were strongly correlated in peritumoral tissues, suggesting a highly co-ordinated glutathione pathway that appeared disrupted in breast tumours with only a few correlations left. Therefore, resistance could spontaneously result from deregulated variations in the glutathione pathway, which might be relevant to the malignant disease progression.

Details

Language :
English
ISSN :
03043835
Database :
OpenAIRE
Journal :
Cancer Letters, Cancer Letters, Elsevier, 2000
Accession number :
edsair.doi.dedup.....3138c12b469cc19d1709c563fde777bc