Additional file 1 of Regular proton pump inhibitor use and incident dementia: population-based cohort study

Additional file 1: Table S1. Disease definitions used in the UK Biobank study. Table S2. The numbers (percentage) of the missing variables. Table S3. Subgroup analysis: associations of regular use of each PPI with the risk of incident dementia. Table S4. Sensitivity analysis: associations of regular PPI Use with the risk of incident dementia after excluding participants with missing covariate data. Table S5. Sensitivity analysis: associations of regular PPI use with the risk of incident dementia after excluding participants who developed outcomes during the first two years of follow-up. Table S6. Sensitivity analysis: associations of regular PPI use with the risk of incident dementia after excluding participants who developed outcomes only recorded on death register data. Figure S1. The cumulative risk of incident all-cause dementia (A), Alzheimer’s disease (B), and vascular dementia (C) according to regular PPI use for each APOE genotype subgroup. Figure S2. Association of regular PPI use and APOE genotype with incident dementia. Figure S3. Association of regular PPI use and modifying factors with incident all-cause dementia. Figure S4. Associations of regular PPI use with incident Alzheimer’s disease stratified by potential risk factors. Figure S5. Associations of regular PPI use with incident vascular dementia stratified by potential risk factors. Figure S6. Associations of regular PPI use with incident dementia stratified by APOE genotype among participants older than 65 years at baseline.