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Molecularly imprinted cryogel membranes for mitomycin C delivery
- Source :
- Journal of Biomaterials Science, Polymer Edition. 28:519-531
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- WOS: 000399567500002<br />PubMed: 28105892<br />In this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests. In vitro delivery studies were carried out to examine the effects of cross-linker ratio and template content. Mitomycin C imprinted cryogel membranes have megaporous structure (10-100 mu m in diameter). The cumulative release of mitomycin C was decreased with increasing cross-linking agent ratio and increased with the amount of template in the cryogel structure. The nature of transport mechanism of the mitomycin C from the membranes was non-Fickian.<br />TUBITAK-BIDEB2211-National Ph.D. Scholarship Programme<br />Kemal Cetin thanks The Scientific and Technological Research Council of Turkey (TUBITAK) for the support by 'TUBITAK-BIDEB2211-National Ph.D. Scholarship Programme'.
- Subjects :
- Materials science
Bulk polymerization
Cell Survival
Surface Properties
Scanning electron microscope
Mitomycin
Acrylic Resins
Biomedical Engineering
Biophysics
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Cell Line
Polymerization
Molecular Imprinting
Biomaterials
Mice
Drug Delivery Systems
Materials Testing
medicine
Animals
Humans
Fourier transform infrared spectroscopy
Chromatography
Mitomycin C
Membranes, Artificial
021001 nanoscience & nanotechnology
In vitro
0104 chemical sciences
Drug Liberation
Cross-Linking Reagents
Membrane
Drug delivery
Cryogel Membrane
Mitomycin C Delivery
Adsorption
Swelling
medicine.symptom
0210 nano-technology
Porosity
Cryogels
Subjects
Details
- ISSN :
- 15685624 and 09205063
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Biomaterials Science, Polymer Edition
- Accession number :
- edsair.doi.dedup.....315515cbadf8ad26b2c12cd6a46a8512