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Microbiota-based markers predictive of development of Clostridioides difficile infection
- Source :
- Dipòsit Digital de la UB, Universidad de Barcelona, Nature communications, Nature Communications 12, 2241 (2021). doi:10.1038/s41467-021-22302-0, Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
- Publication Year :
- 2021
- Publisher :
- RWTH Aachen University, 2021.
-
Abstract
- Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile infection (CDI), which is associated with considerable morbidity, mortality, and healthcare-costs globally. Therefore, identification of markers predictive of CDI could substantially contribute to guiding therapy and decreasing the infection burden. Here, we analyze the intestinal microbiota of hospitalized patients at increased CDI risk in a prospective, 90-day cohort-study before and after antibiotic treatment and at diarrhea onset. We show that patients developing CDI already exhibit significantly lower diversity before antibiotic treatment and a distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients. We find that antibiotic treatment-induced dysbiosis is class-specific with beta-lactams further increasing enterococcal abundance. Our findings, validated in an independent prospective patient cohort developing CDI, can be exploited to enrich for high-risk patients in prospective clinical trials, and to develop predictive microbiota-based diagnostics for management of patients at risk for CDI.<br />Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.
- Subjects :
- 0301 basic medicine
Male
Malalties bacterianes grampositives
genetic structures
Antibiotics
Medizin
General Physics and Astronomy
Prevotella
Prospective Studies
Prospective cohort study
Bifidobacterium
Multidisciplinary
biology
Microbiota
Middle Aged
3. Good health
Anti-Bacterial Agents
Diarrhea
Cohort
Female
medicine.symptom
Engineering sciences. Technology
medicine.medical_specialty
medicine.drug_class
Science
030106 microbiology
Predictive markers
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
Internal medicine
medicine
Humans
Microbiome
Aged
Gram-positive bacterial infections
Bacteria
business.industry
Clostridioides difficile
General Chemistry
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
030104 developmental biology
Next-generation sequencing
Clostridium Infections
Human medicine
business
Dysbiosis
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de la UB, Universidad de Barcelona, Nature communications, Nature Communications 12, 2241 (2021). doi:10.1038/s41467-021-22302-0, Nature Communications, Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
- Accession number :
- edsair.doi.dedup.....31581eff8291ed2ca591055cf71ef90c
- Full Text :
- https://doi.org/10.18154/rwth-conv-248277