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Recent advances on Candida albicans biology and virulence
- Source :
- F1000Research
- Publication Year :
- 2016
- Publisher :
- F1000Research, 2016.
-
Abstract
- Candida albicans is an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, and increasing resistance to the front-line therapeutics, demonstrating a clear need for new antifungal drugs. Understanding the biology of this pathogen is an important prerequisite for identifying new drug targets for antifungal therapeutics. In this review, we highlight some recent developments that help us to understand how virulence traits are regulated at the molecular level, in addition to technical advances that improve the ability of genome editing in C. albicans.
- Subjects :
- 0301 basic medicine
Drug
Antifungal drugs
media_common.quotation_subject
030106 microbiology
Virulence
Review
General Biochemistry, Genetics and Molecular Biology
Microbial Physiology & Metabolism
Microbiology
03 medical and health sciences
Genome editing
C. albicans
Flora (microbiology)
Candida albicans
Environmental Microbiology
antifungal drugs
genome editing
Cellular Microbiology & Pathogenesis
General Pharmacology, Toxicology and Pharmaceutics
Pathogen
media_common
General Immunology and Microbiology
biology
Microbial Evolution & Genomics
General Medicine
Articles
Genomics
biology.organism_classification
Corpus albicans
3. Good health
virulence
030104 developmental biology
Medical Microbiology
Microbial Growth & Development
Control of Gene Expression
Subjects
Details
- Language :
- English
- ISSN :
- 20461402
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- F1000Research
- Accession number :
- edsair.doi.dedup.....316c2cc4e68cf61131248b15e2f2fef0