Study on the Inclusion Complex of Rutin/Sulfobutylether-β-Cyclodextrin

The inclusion complexes of rutin/sulfobutylether-β-cyclodextrin (SBE-β-CD) were prepared by grinding, co-precipitation and ultrasonic method and then identified with differential scanning calorimetry (DSC) and UV-visible spectrophotometry (UV). The molar ratio 1∶1 of rutin to SBE-β-CD in the complex was confirmed by phase solubility studies, and the dissolutions of rutin/SBE-β-CD were investigated by UV. The dissolution of rutin included in the complex showed significant increases in aqueous solution. The rutin/SBE-β-CD inclusion complex exhibited unique physical characteristics that are different from rutin.