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Immune responses to viral infections: Relevance for asthma
- Source :
- Paediatric Respiratory Reviews. 7:S125-S127
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Summary Severe respiratory viral infections in childhood are associated with the development of asthma later in life. Rhinovirus, respiratory syncytial virus and metapneumovirus are of particular importance as triggers of asthma. Effects of virus infection on dendritic cell function in the airways may predispose children to allergic sensitization. Asthmatic subjects may have impaired interferon responses to viral infection that also predispose to allergic sensitization. Difference in Toll-like receptor expression on airway epithelial cells is a potential mechanism for the altered immune responses of asthmatic children.
- Subjects :
- Pulmonary and Respiratory Medicine
T-Lymphocytes
viruses
Receptor expression
Respiratory Mucosa
medicine.disease_cause
Virus
Allergic sensitization
Immune system
Interferon
medicine
Humans
Child
Respiratory Tract Infections
Asthma
Immunity, Cellular
business.industry
Toll-Like Receptors
Dendritic cell
respiratory system
medicine.disease
Virology
respiratory tract diseases
Virus Diseases
Pediatrics, Perinatology and Child Health
Immunology
Rhinovirus
business
medicine.drug
Subjects
Details
- ISSN :
- 15260542
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Paediatric Respiratory Reviews
- Accession number :
- edsair.doi.dedup.....3192ccf19eb9b8392b995b4b64cb7724