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Associations between Levels of Urinary Oxidative Stress of 8-OHdG and Risk of Atopic Diseases in Children
- Source :
- International Journal of Environmental Research and Public Health, Volume 17, Issue 21
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- The oxidative stress biomarker of urinary 8-hydroxy-2&prime<br />deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age- and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner<br />(2) Children&rsquo<br />s AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus<br />(3) For children with AD, urinary 8-OHdG levels of &gt<br />75th percentile were associated with higher risk of asthma, compared with the reference group of 0&ndash<br />25th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.
- Subjects :
- Male
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Urinary system
Taiwan
medicine.disease_cause
Article
Dermatitis, Atopic
urinary 8-OhdG
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
oxidative stress
In patient
Child
030304 developmental biology
Asthma
0303 health sciences
atopic dermatitis
business.industry
Public Health, Environmental and Occupational Health
Deoxyguanosine
Atopic dermatitis
Environmental Exposure
asthma
medicine.disease
8-Hydroxy-2'-Deoxyguanosine
Case-Control Studies
Child, Preschool
Biomarker (medicine)
Female
atopic diseases
business
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 16604601
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....31a20da292bdd4d5baad09c045ff5770
- Full Text :
- https://doi.org/10.3390/ijerph17218207