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Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression
- Source :
- BMJ Case Rep
- Publication Year :
- 2020
-
Abstract
- A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel perforation secondary to immunotherapy driven rapid tumour regression was made. The patient was treated with a small bowel resection plus anastomosis and made a full recovery. This case highlights the rare potential side effect of immunotherapy in causing non-inflammatory bowel perforations secondary to rapid tumour regression.
- Subjects :
- Male
medicine.medical_specialty
Skin Neoplasms
Side effect
Perforation (oil well)
Testicular pain
Ipilimumab
Anastomosis
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Antineoplastic Agents, Immunological
medicine
Humans
Melanoma
Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
business.industry
General Medicine
Middle Aged
medicine.disease
medicine.anatomical_structure
Nivolumab
Intestinal Perforation
030220 oncology & carcinogenesis
Abdomen
Neoplasms, Unknown Primary
Radiology
Immunotherapy
Skin cancer
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 13
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- BMJ case reports
- Accession number :
- edsair.doi.dedup.....31b427e0023fa51e54381a79679b9567