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Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression

Authors :
Lennard Yw Lee
Arvind Tripathy
Kishen Rajan Patel
David McKean
Source :
BMJ Case Rep
Publication Year :
2020

Abstract

A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel perforation secondary to immunotherapy driven rapid tumour regression was made. The patient was treated with a small bowel resection plus anastomosis and made a full recovery. This case highlights the rare potential side effect of immunotherapy in causing non-inflammatory bowel perforations secondary to rapid tumour regression.

Details

ISSN :
1757790X
Volume :
13
Issue :
2
Database :
OpenAIRE
Journal :
BMJ case reports
Accession number :
edsair.doi.dedup.....31b427e0023fa51e54381a79679b9567