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Atrial involvement in arrhythmogenic right ventricular cardiomyopathy patients referred for ventricular arrhythmias ablation
- Source :
- Journal of Cardiovascular Electrophysiology. 29:1388-1395
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable myocardium disorder that predominantly affects the ventricle. Little is known about atrial involvement. This study aimed to assess atrial involvement, especially the role of genotype on atrium in ARVC. METHODS The incidence, characterization and predictors of atrial involvement were investigated. Nine known ARVC-causing genes were screened and the correlation between genotype and atrial involvement was assessed. RESULTS Right atrium (RA) dilation, left atrium (LA) dilation, and sustained atrial tachyarrhythmias (ATa) were found in 45, 16 and 3 patients, respectively. Gene mutations were identified in 64 (64.0%) patients. Mutation carriers showed more RA dilation than noncarriers (54.7% vs. 27.8%, P = 0.009), and no difference in LA dilation and ATa. Multivariate analysis showed tricuspid regurgitation (OR: 18.867; 95% CI: 1.466-250.000; P = 0.024) increased the risk of RA dilation and decreased left ventricular ejection fraction (LVEF) (OR: 1.134; 95% CI: 1.002-1.272; P = 0.031) correlated with LA dilation, whereas genotype showed no significant effect. At a median follow-up time of 91 months, 7 patients died and 1 patient accepted heart transplantation. New-onset RA dilation, LA dilation, and sustained ATa were found in 8, 7, and 6 patients, respectively. Atrial involvement was not associated with the long-term survival. Despite mutation carriers showing more RA dilation, Kaplan-Meier analysis showed genotype was not associated with atrial involvement. CONCLUSION Atrial involvement was common in ARVC. Tricuspid regurgitation and decreased LVEF increased the risk for atrial dilation. Genotype was not associated with atrial involvement.
- Subjects :
- Male
0301 basic medicine
Time Factors
Action Potentials
Atrial Function, Right
030204 cardiovascular system & hematology
Gene mutation
0302 clinical medicine
Heart Rate
Risk Factors
Atrial Fibrillation
Tachycardia, Supraventricular
Referral and Consultation
Arrhythmogenic Right Ventricular Dysplasia
Ejection fraction
Atrial fibrillation
Middle Aged
Phenotype
Treatment Outcome
medicine.anatomical_structure
Atrial Flutter
Catheter Ablation
cardiovascular system
Cardiology
Atrial Function, Left
Female
Cardiology and Cardiovascular Medicine
Anti-Arrhythmia Agents
Adult
medicine.medical_specialty
Right ventricular cardiomyopathy
Young Adult
03 medical and health sciences
Physiology (medical)
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Heart Atria
cardiovascular diseases
Atrium (architecture)
business.industry
Atrial Remodeling
Myocardium disorder
medicine.disease
030104 developmental biology
Ventricle
Mutation
Heart Transplantation
business
Atrial flutter
Subjects
Details
- ISSN :
- 10453873
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiovascular Electrophysiology
- Accession number :
- edsair.doi.dedup.....31c0e9b798f049c633c380ea7d1fe61d