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Lower Corticosteroid Skin Blanching Response Is Associated with Severe COPD
- Source :
- PLoS ONE, 9(3):e91788. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 9, Iss 3, p e91788 (2014), PLoS ONE
- Publication Year :
- 2014
-
Abstract
- Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by ongoing inflammatory and remodeling processes of the airways and lung tissue. Inflammation can be targeted by corticosteroids. However, airway inflammation is generally less responsive to steroids in COPD than in asthma. The underlying mechanisms are yet unclear. This study aimed to assess whether skin corticosteroid insensitivity is associated with COPD and COPD severity using the corticosteroid skin blanching test. Methods COPD patients GOLD stage I–IV (n = 27, 24, 22, and 16 respectively) and healthy never-smokers and smokers (n = 28 and 56 respectively) were included. Corticosteroid sensitivity was assessed by the corticosteroid skin blanching test. Budesonide was applied in 8 logarithmically increasing concentrations (0–100 μg/ml) on subject's forearm. Assessment of blanching was performed after 7 hours using a 7-point scale (normal skin to intense blanching). All subjects performed spirometry and body plethysmography. Results Both GOLD III and GOLD IV COPD patients showed significantly lower skin blanching responses than healthy never-smokers and smokers, GOLD I, and GOLD II patients. Their area under the dose-response curve values of the skin blanching response were 586 and 243 vs. 1560, 1154, 1380, and 1309 respectively, p
- Subjects :
- Male
Budesonide
TORCH
Pulmonology
Chronic Obstructive Pulmonary Diseases
Epidemiology
lcsh:Medicine
INHALED CORTICOSTEROIDS
Gastroenterology
Pulmonary Disease, Chronic Obstructive
FLUTICASONE
Adrenal Cortex Hormones
lcsh:Science
Skin
COPD
Multidisciplinary
medicine.diagnostic_test
PLACEBO
Pigmentation
Smoking
Middle Aged
PROPIONATE
Medicine
Corticosteroid
Female
SENSITIVITY
Research Article
medicine.drug
Spirometry
Drugs and Devices
medicine.medical_specialty
Clinical Research Design
Blanching
medicine.drug_class
Color
PHENOTYPES
Dermatology
Placebo
OBSTRUCTIVE PULMONARY-DISEASE
Internal medicine
medicine
Humans
Plethysmograph
Pharmacokinetics
GLUCOCORTICOIDS
Aged
Asthma
Inflammation
business.industry
Pharmacoepidemiology
lcsh:R
Immunity
Smoking Related Disorders
STANDARDIZATION
medicine.disease
Surgery
respiratory tract diseases
body regions
Case-Control Studies
Clinical Immunology
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 9(3):e91788. PUBLIC LIBRARY SCIENCE, PLoS ONE, Vol 9, Iss 3, p e91788 (2014), PLoS ONE
- Accession number :
- edsair.doi.dedup.....31c25f45cf3cacfe73ec14e747f4c6fc