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Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1
- Source :
- Cell Death and Disease, Vol 11, Iss 7, Pp 1-16 (2020), Cell Death & Disease
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- Growing evidences illustrated that long non-coding RNAs (lncRNAs) exhibited widespread effects on the progression of human cancers via various mechanisms. Long intergenic non-protein-coding RNA 01446 (LINC01446), a 3484-bp ncRNA, is known to locate at chromosome 7p12.1. However, its biological functions and specific action mechanism in gastric cancer (GC) are still unclear. In our study, LINC01446 was proved to be markedly upregulated in GC tissues relative to the normal tissues, and positively correlated with the poor survival of GC patients. The multivariate Cox regression model showed that LINC01446 functioned as an independent prognostic factor for the survival of GC patients. Functionally, LINC01446 facilitated the proliferation and metastasis of GC cells. Moreover, RNA-seq analysis demonstrated that LINC01446 knockdown primarily regulated the genes relating to the growth and migration of GC. Mechanistically, LINC01446 could widely interact with histone lysine-specific demethylase LSD1 and recruit LSD1 to the Ras-related dexamethasone-induced 1 (RASD1) promoter, thereby suppressing RASD1 transcription. Overall, these findings suggest that LINC01446/LSD1/RASD1 regulatory axis may provide bona fide targets for anti-GC therapies.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Immunology
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Cancer epidemiology
Transcription (biology)
Stomach Neoplasms
Humans
Neoplasm Metastasis
lcsh:QH573-671
Gene
Cell Proliferation
Histone Demethylases
Gene knockdown
biology
lcsh:Cytology
RNA
Cell Biology
Middle Aged
Non-coding RNA
030104 developmental biology
Histone
030220 oncology & carcinogenesis
Cancer cell
biology.protein
Cancer research
Disease Progression
Demethylase
Female
RNA, Long Noncoding
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Volume :
- 11
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Cell Death and Disease
- Accession number :
- edsair.doi.dedup.....31d5531a4fd021d3408b214cce007126
- Full Text :
- https://doi.org/10.1038/s41419-020-2729-0