Hypoxemia in infants with trisomy 21 in the neonatal intensive care unit

Objective Newborns with Trisomy 21 (T21) often require NICU hospitalization. Oxygen desaturations are frequently observed in these infants, even in the absence of congenital heart defects (CHD). We hypothesized that T21 NICU patients have more hypoxemia than those without T21. Design All infants with T21 without significant CHD discharged home from the NICU between 2009–2018 were included (n=23). Controls were matched 20:1 for gestational age and length of stay. We compared daily severe hypoxemia events (SpO2