Back to Search
Start Over
Long-term outcomes of Roux-en-Y gastric bypass versus medical therapy for patients with type 2 diabetes: a meta-analysis of randomized controlled trials
- Source :
- Surgery for Obesity and Related Diseases. 17:1334-1343
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Roux-en-Y gastric bypass (RYGB) has been widely used for type 2 diabetes (T2D) patients with overweight or obesity. However, the long-term outcomes of RYGB versus medical therapy have not been well compared.To evaluate the long-term outcomes of RYGB versus medical therapy for patients with T2D.University-affiliated hospital, China.Four electronic databases-PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov-were searched for articles published through February 2021. Eligible studies were randomized controlled trials.Of 7 randomized controlled trials (15 articles), 477 patients were included: 239 were randomly divided into RYGB groups and 238 to medical therapy groups. Statistically higher rates of T2D remission were observed in RYGB groups at 1 year (relative risk [RR], 18.01; 95% confidence interval [CI], 4.53- 71.70; P.0001), 3 years (RR, 29.58; 95% CI, 5.92-147.82; P.0001), and 5 years (RR, 16.92; 95% CI, 4.15-69.00; P.0001). Meanwhile, statistically higher rates of achieving the American Diabetes Association's (ADA's) treatment goal were observed in RYGB groups at 1 year (RR, 3.99; 95% CI, 1.01-15.82; P = .05), 2 years (RR, 2.98; 95% CI, 1.62- 5.48; P = .0004), 3 years (RR, 3.16; 95% CI, 1.33-7.49; P = .009), and 5 years (RR, 6.18; 95% CI, 1.69-22.68; P = .006).This meta-analysis indicated that RYGB led to higher rates of T2D remission than medical therapy at 1, 3, and 5 years, as well as higher rates of achieving ADA's composite goal at 1, 2, 3, and 5 years.
- Subjects :
- China
medicine.medical_specialty
Gastric Bypass
030209 endocrinology & metabolism
Type 2 diabetes
Overweight
Cochrane Library
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Humans
Randomized Controlled Trials as Topic
business.industry
nutritional and metabolic diseases
medicine.disease
Roux-en-Y anastomosis
Confidence interval
Obesity, Morbid
Surgery
Treatment Outcome
Diabetes Mellitus, Type 2
Relative risk
Meta-analysis
030211 gastroenterology & hepatology
medicine.symptom
business
Subjects
Details
- ISSN :
- 15507289
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Surgery for Obesity and Related Diseases
- Accession number :
- edsair.doi.dedup.....31f7a63ace179df7200922b9c1ae3c90