Back to Search
Start Over
Evaluation of Slug expression is useful for predicting lymph node metastasis and survival in patients with gastric cancer
- Source :
- BMC Cancer, BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Slug is a transcription factor that activates the epithelial–mesenchymal transition (EMT) process in cancer progression. The aim of our study was to evaluate the clinical significance of Slug expression in gastric cancer. Methods The expression of Slug in gastric cancer tissues of 456 patients who underwent gastrectomy was evaluated by immunohistochemistry using tissue microarrays. Slug expression level was defined by the composite score determined by multiplying the tumor staining scores for intensity and extent. The associations of Slug expression with clinicopathological characteristics and overall and recurrence-free survival were analyzed. Results Patients were divided into three groups according to Slug composite score (≤4, 6, and 9). Low, mid, and high expression of Slug was observed in 104 (22.7%), 130 (28.3%), and 225 (49.0%) of cases, respectively. Overall survival and recurrence-free survival progressively increased from high to low Slug expression. In terms of lymph node metastasis, the rate of positive lymph node metastasis was 38/104 (36.5%), 79/130 (60.8%), and 178/225 (79.1%) in low, mid, and high Slug expression groups, respectively, displaying a tendency to increase with higher Slug expression. In a multivariate analysis adjusting for patient age, tumor size, tumor depth, and histology, high Slug expression was associated with a high rate of positive lymph node metastasis compared with low Slug expression (odds ratio 3.42; 95% confidence interval, 1.74–6.69). In a subgroup analysis of T1 cancer, patients with negative Slug expression (defined as
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
Metastasis
Tissue microarray
0302 clinical medicine
Surgical oncology
Early Detection of Cancer
Aged, 80 and over
biology
Epithelial–mesenchymal transition
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Slug
Gene Expression Regulation, Neoplastic
030220 oncology & carcinogenesis
Lymphatic Metastasis
embryonic structures
Immunohistochemistry
Female
Research Article
Adult
medicine.medical_specialty
animal structures
Epithelial-Mesenchymal Transition
lcsh:RC254-282
Disease-Free Survival
03 medical and health sciences
Gastrectomy
Stomach Neoplasms
Internal medicine
Genetics
medicine
Biomarkers, Tumor
Humans
Aged
business.industry
fungi
Cancer
medicine.disease
biology.organism_classification
Early Gastric Cancer
030104 developmental biology
Tissue Array Analysis
Snail Family Transcription Factors
business
Gastric cancer
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....3201123d83fed30f5599c6ae4d764722