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Congenital laryngomalacia is related to exercise-induced laryngeal obstruction in adolescence
- Source :
- Archives of Disease in Childhood
- Publication Year :
- 2016
- Publisher :
- BMJ Publishing Group, 2016.
-
Abstract
- ObjectivesCongenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life.MethodsTwenty of 23 (87%) infants hospitalised at Haukeland University Hospital during 1990–2000 for CLM without comorbidities and matched controls were assessed at mean age 13 years. Past and current respiratory morbidity was recorded in a questionnaire, and spirometry performed according to standard quality criteria. Laryngoscopy was performed at rest and continuously throughout a maximal treadmill exercise test (continuous laryngoscopy exercise test (CLE-test)), and scored and classified in a blinded fashion according to preset criteria.ResultsIn the CLM group, laryngeal anatomy supporting CLM in infancy was described at rest in nine (45%) adolescents. Eleven (55%) reported breathing difficulties in relation to exercise, of whom 7 had similarities to CLM at rest and 10 had supraglottic obstruction during CLE-test. Overall, 6/20 had symptoms during exercise and similarities to CLM at rest and obstruction during CLE-test. In the control group, one adolescent reported breathing difficulty during exercise and two had laryngeal obstruction during CLE-test. The two groups differed significantly from each other regarding laryngoscopy scores, obtained at rest and during exercise (p=0.001 or less).ConclusionsCLM had left footprints that increased the risk of later exercise-induced symptoms and laryngeal obstruction. The findings underline the heterogeneity of childhood respiratory disease and the importance of considering early life factors.
- Subjects :
- Larynx
Spirometry
Male
Pediatrics
medicine.medical_specialty
Adolescent
Stridor
Vocal cord dysfunction
Laryngoscopy
Laryngomalacia
03 medical and health sciences
Respiratory Disorders
Young Adult
0302 clinical medicine
Exercise induced inspiratory symptoms
Surveys and Questionnaires
medicine
Humans
030223 otorhinolaryngology
Child
Congenital laryngomalacia
medicine.diagnostic_test
business.industry
Follow-up study
Infant
Airway obstruction
medicine.disease
Laryngeal Obstruction
Airway Obstruction
medicine.anatomical_structure
030228 respiratory system
Anesthesia
Pediatrics, Perinatology and Child Health
Exercise Test
Original Article
Female
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14682044 and 00039888
- Volume :
- 101
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Archives of Disease in Childhood
- Accession number :
- edsair.doi.dedup.....3202e2ceb6cf5647d34283c76c69dba0