A New Strategy To Construct Acyclic Nucleosides via Ag(I)-Catalyzed Addition of Pronucleophiles to 9-Allenyl-9H-purines

Authors :: Hai-Ming Guo
Tao Wei
Ming-Sheng Xie
Gui-Rong Qu
Hong-Ying Niu
Source :: Organic Letters. 16:900-903
Publication Year :: 2014
Publisher :: American Chemical Society (ACS), 2014.
Abstract: A new strategy to construct acyclic nucleosides with diverse side chains was developed. With Ag(I) salts as catalysts, the hydrocarboxylation, hydroamination, and hydrocarbonation reactions proceeded well, affording acyclic nucleosides in good yields (41 examples, 60-98% yields). Meanwhile, these reactions exhibited high chemoselectivities and E-selectivities.

Subjects :: Silver
Molecular Structure
Chemistry
Organic Chemistry
Nucleosides
Biochemistry
Catalysis
Purines
Side chain
Organic chemistry
Hydroamination
Physical and Theoretical Chemistry
Purine metabolism
Amination

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