Back to Search
Start Over
Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk
- Source :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Cancer Epidemiology Biomarkers and Prevention, 30(12), 2342-2345. American Association for Cancer Research Inc., Cancer epidemiology, biomarkers & prevention, 30(12), 2342-2345. American Association for Cancer Research Inc.
- Publication Year :
- 2021
- Publisher :
- AMER ASSOC CANCER RESEARCH, 2021.
-
Abstract
- Background: The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC etiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNP) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. Methods: We conducted a two-phase association study of mtSNPs and n-mtSNPs to assess their effect on PDAC risk. We analyzed 35,297 n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases and 42,986 controls). In addition, we also conducted a gene-based analysis on 1,588 genes involved in mitochondrial metabolism using Multi-marker Analysis of GenoMic Annotation (MAGMA) software. Results: In the discovery phase, we identified 49 n-mtSNPs and no mtSNPs associated with PDAC risk (P < 0.05). In the second phase, none of the findings were replicated. In the gene-level analysis, we observed that three genes (TERT, SUGCT, and SURF1) involved in the mitochondrial metabolism showed an association below the Bonferroni-corrected threshold of statistical significance (P = 0.05/1588 = 3.1 × 10−5). Conclusions: Even though the mitochondrial metabolism might be involved in PDAC etiology, our results, obtained in a study with one of the largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are associated with PDAC risk. Impact: This large case–control study does not support a role of the genetic variability of the mitochondrial function in PDAC risk.
- Subjects :
- Mitochondrial DNA
Pancreatic ductal adenocarcinoma
Nuclear gene
endocrine system diseases
Epidemiology
Biology
SUSCEPTIBILITY
Polymorphism, Single Nucleotide
SDG 3 - Good Health and Well-being
Pancreatic cancer
medicine
Humans
03.02. Klinikai orvostan
Genetic variability
Carcinoma, Pancreatic Ductal
Case-Control Studies
Genetic Variation
Genome, Mitochondrial
Mitochondria
Pancreatic Neoplasms
Polymorphism
GENOME-WIDE ASSOCIATION
Gene
Genetics
Genome
GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY
Carcinoma
Single Nucleotide
Metabolism
medicine.disease
digestive system diseases
Mitochondrial
Oncology
Pancreatic Ductal
Subjects
Details
- Language :
- English
- ISSN :
- 10559965
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Cancer Epidemiology Biomarkers and Prevention, 30(12), 2342-2345. American Association for Cancer Research Inc., Cancer epidemiology, biomarkers & prevention, 30(12), 2342-2345. American Association for Cancer Research Inc.
- Accession number :
- edsair.doi.dedup.....3225139b188d1eeec9667b08fdc4095e