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Utility of T2 mapping in the staging of thyroid-associated ophthalmopathy: efficiency of region of interest selection methods
- Source :
- Acta Radiologica. 61:1512-1519
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Background Discriminating the stage of thyroid-associated ophthalmopathy (TAO) is crucial for the treatment strategy and prognosis prediction. Utility of conventional magnetic resonance imaging in the disease staging is limited. Purpose To investigate the performance of T2 mapping based on different region of interest (ROI) selection methods in the staging of TAO. Material and Methods Thirty-two patients with TAO were retrospectively enrolled. Two radiologists independently measured the T2 relaxation time (T2RT) of extraocular muscles using two different ROIs (hotspot [ROIHS]: T2RT-hot; single-slice [ROISS]: T2RT-mean, T2RT-max, T2RT-min). Independent-samples t test, Wilcoxon signed rank test, Spearman correlation analysis, receiver operating characteristic (ROC) curves analyses, multiple ROC comparisons, and intra-class correlation coefficient (ICC) were used for statistical analyses. Results No significant difference was found in the measuring time between ROIHS and ROISS methods ( P = 0.066). T2RT-mean demonstrated the highest ICC for measurement, followed by T2RT-max and T2RT-min, and T2RT-hot showed the poorest reproducibility. Active TAOs showed significantly higher values for all the T2RTs than inactive mimics (all P Conclusion The T2RTs derived from both ROI selection methods could be useful for the staging of TAO. The results of measuring time, reproducibility, and diagnostic performance suggest that T2RT-max would be the optimal indicator for staging.
- Subjects :
- Male
Prognosis prediction
medicine.medical_specialty
T2 mapping
Eye
Severity of Illness Index
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Region of interest
medicine
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Thyroid-Associated Ophthalmopathy
Retrospective Studies
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Reproducibility of Results
Magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
Graves Ophthalmopathy
Treatment strategy
Female
Selection method
Radiology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16000455 and 02841851
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Acta Radiologica
- Accession number :
- edsair.doi.dedup.....3227c0143727c1a149294b6354418558