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A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate MEF2D and bcl-w
- Source :
- The Journal of Neuroscience. 29:6700-6709
- Publication Year :
- 2009
- Publisher :
- Society for Neuroscience, 2009.
-
Abstract
- Survival and maturation of dorsal root ganglia sensory neurons during development depend on target-derived neurotrophins. These target-derived signals must be transmitted across long distances to alter gene expression. Here, we address the possibility that long-range retrograde signals initiated by target-derived neurotrophins activate a specialized transcriptional program. The transcription factor MEF2D is expressed in sensory neurons; we show that expression of this factor is induced in response to target-derived neurotrophins that stimulate the distal axons. We demonstrate that MEF2D regulates expression of an anti-apoptoticbcl-2family member,bcl-w. Expression ofmef2dandbcl-wis stimulated in response to activation of a Trk-dependent ERK5/MEF2 pathway, and our data indicate that this pathway promotes sensory neuron survival. We find thatmef2dandbcl-ware members of a larger set of retrograde response genes, which are preferentially induced by neurotrophin stimulation of distal axons. Thus, activation of an ERK5/MEF2D transcriptional program establishes and maintains the cellular constituents of functional sensory circuits.
- Subjects :
- Mef2
Sensory Receptor Cells
Cell Survival
Green Fluorescent Proteins
Nerve Tissue Proteins
Stimulation
Transfection
Article
Ganglia, Spinal
Chlorocebus aethiops
In Situ Nick-End Labeling
medicine
Animals
Nerve Growth Factors
RNA, Messenger
Enzyme Inhibitors
Cells, Cultured
Mitogen-Activated Protein Kinase 7
Regulation of gene expression
biology
General Neuroscience
Embryo, Mammalian
Protein Tyrosine Phosphatases, Non-Receptor
Sensory neuron
Rats
Cell biology
Nerve growth factor
medicine.anatomical_structure
Gene Expression Regulation
Proto-Oncogene Proteins c-bcl-2
nervous system
biology.protein
RNA Interference
Signal transduction
Signal Transduction
Neurotrophin
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....322f57e41d65c4e13472f56172e46630