Back to Search
Start Over
Correction to: Pegvisomant in acromegaly: an update
- Source :
- Journal of Endocrinological Investigation
- Publication Year :
- 2017
- Publisher :
- Springer International Publishing, 2017.
-
Abstract
- Background In 2007, we published an opinion document to review the role of pegvisomant (PEG) in the treatment of acromegaly. Since then, new evidence emerged on the biochemical and clinical effects of PEG and on its long-term efficacy and safety. Aim We here reviewed the emerging aspects of the use of PEG in clinical practice in the light of the most recent literature. Results The clinical use of PEG is still suboptimal, considering that it remains the most powerful tool to control IGF-I in acromegaly allowing to obtain, with a pharmacological treatment, the most important clinical effects in terms of signs and symptoms, quality of life and comorbidities. The number of patients with acromegaly exposed to PEG worldwide has become quite elevated and the prolonged follow-up allows now to deal quite satisfactorily with many clinical issues including major safety issues, such as the concerns about possible tumour (re)growth under PEG. The positive or neutral impact of PEG on glucose metabolism has been highlighted, and the clinical experience, although limited, with sleep apnoea and pregnancy has been reviewed. Finally, the current concept of somatostatin receptor ligands (SRL) resistance has been addressed, in order to better define the acromegaly patients to whom the PEG option may be offered. Conclusions PEG increasingly appears to be an effective and safe medical option for many patients not controlled by SRL but its use still needs to be optimized.
- Subjects :
- Heading (navigation)
Endocrinology, Diabetes and Metabolism
Pegvisomant
Review
computer.software_genre
Column (database)
Endocrinology
Acromegaly
medicine
Animals
Humans
business.industry
Human Growth Hormone
Published Erratum
SRL resistance
Correction
medicine.disease
Metabolic effects
IGF-I
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Artificial intelligence
business
computer
Sentence
Natural language processing
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....3231bc03962709803f8ebbff708d8b0b