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The comparison of pathology in ferrets infected by H9N2 avian influenza viruses with different genomic features
- Source :
- Virology. 488
- Publication Year :
- 2015
-
Abstract
- H9N2 avian influenza virus circulates widely in poultry and has been responsible for sporadic human infections in several regions. Few studies have been conducted on the pathogenicity of H9N2 AIV isolates that have different genomic features. We compared the pathology induced by a novel reassortant H9N2 virus and two currently circulating H9N2 viruses that have different genomic features in ferrets. The results showed that the three viruses can induce infections with various amounts of viral shedding in ferrets. The novel H9N2 induced respiratory infection, but no pathological lesions were observed in lung tissues. The other two viruses induced mild to intermediate pathological lesions in lung tissues, although the clinical signs presented mildly in ferrets. The pathological lesions presented a diversity consistent with viral replication in ferrets.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
animal diseases
viruses
Avian influenza virus
Biology
medicine.disease_cause
Virus Replication
Virus
Birds
03 medical and health sciences
Orthomyxoviridae Infections
Virology
Reassortant Viruses
medicine
Influenza A Virus, H9N2 Subtype
Pathogenicity
Animals
Viral shedding
Lung
Microscopy
Histocytochemistry
Ferrets
food and beverages
virus diseases
Respiratory infection
Genetic Variation
respiratory system
H9N2
Influenza A virus subtype H5N1
Virus Shedding
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Viral replication
Influenza in Birds
Subjects
Details
- ISSN :
- 10960341
- Volume :
- 488
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....3235d32f21e009308e0f54160d3319d5