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Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson's disease
- Source :
- Parkinsonismrelated disorders. 56
- Publication Year :
- 2018
-
Abstract
- Introduction Low body weight in Parkinson's disease (PD) is poorly understood despite the associated risks of malnutrition, fractures, and death. Sarcopenia (loss of muscle bulk and strength) and frailty are geriatric syndromes that are likewise associated with adverse health outcomes, yet have received scant attention in PD. We studied body composition, sarcopenia, frailty, and their clinico-biological correlates in PD. Methods 93 patients and 78 spousal/sibling controls underwent comprehensive assessment of diet, clinical status, muscle strength/performance, frailty, body composition (using dual-energy X-ray absorptiometry), and serum levels of neurogastrointestinal hormones and inflammatory markers. Results PD patients were older than controls (66.0 ± 8.5 vs. 62.4 ± 8.4years, P = 0.003). Mean body mass index (24.0 ± 0.4 vs. 25.6 ± 0.5kg/m2, Padjusted = 0.016), fat mass index (7.4 ± 0.3 vs. 9.0 ± 0.3kg/m2, Padjusted Conclusions We found reduced body fat with relatively preserved skeletal muscle mass, and a high prevalence of frailty, in PD. Further studies are needed to understand the patho-mechanisms underlying these alterations.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Sarcopenia
Parkinson's disease
Disease
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Absorptiometry, Photon
Weight loss
Internal medicine
medicine
Humans
Muscle Strength
Sibling
Aged
Anthropometry
Frailty
business.industry
Parkinson Disease
Middle Aged
medicine.disease
Malnutrition
030104 developmental biology
Cross-Sectional Studies
Neurology
Adipose Tissue
Body Composition
Female
Neurology (clinical)
Geriatrics and Gerontology
medicine.symptom
business
Body mass index
030217 neurology & neurosurgery
Hormone
Subjects
Details
- ISSN :
- 18735126
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Parkinsonismrelated disorders
- Accession number :
- edsair.doi.dedup.....324eaa40f54565fb0983a549b2a0fd58