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N,N-Dimethylsphingosine−Coumarin: Synthesis, Chemical Characterization, and Biological Evaluation
- Source :
- Bioconjugate Chemistry. 18:731-735
- Publication Year :
- 2007
- Publisher :
- American Chemical Society (ACS), 2007.
-
Abstract
- Coumarin derivatives of N,N-dimethylsphingosine (DMSP) were prepared and chemically characterized. They were apparently biologically equivalent to DMSP in terms of tumor cell cytotoxicity and were used to establish the rapid mitochondrial localization of this sphingolipid in tumor cells, followed closely by its marked reduction of mitochondrial membrane potential.
- Subjects :
- Membrane Potential, Mitochondrial
Pharmacology
Membrane potential
Chemistry
Stereochemistry
Organic Chemistry
Biomedical Engineering
Pharmaceutical Science
Bioengineering
Tumor cells
Coumarin
Coumarin synthesis
Sphingolipid
Mitochondria
chemistry.chemical_compound
Microscopy, Fluorescence
Biochemistry
Coumarins
Sphingosine
Cell Line, Tumor
Humans
Mitochondrial localization
Cytotoxicity
Biotechnology
Biological evaluation
Subjects
Details
- ISSN :
- 15204812 and 10431802
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Bioconjugate Chemistry
- Accession number :
- edsair.doi.dedup.....325fd9c283058051ec7c6737e647e65e