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C3, C3AR1, HLA-DRA, and HLA-E as potential prognostic biomarkers for renal clear cell carcinoma
- Source :
- Transl Androl Urol
- Publication Year :
- 2020
- Publisher :
- AME Publishing Company, 2020.
-
Abstract
- BACKGROUND: Prognostic biomarkers play a vital role in the early detection of the cancer and assessment of prognosis. With advances in technology, a large number of biomarkers of kidney renal clear cell carcinoma (KIRC) have been discovered, but their prognostic value has not been fully investigated, and thus have not been widely used in clinical practice. We aimed to identify the reliable markers associated with the prognosis of KIRC patients. METHODS: We obtained 72 normal samples and 539 tumor samples from The Cancer Genome Atlas (TCGA), and 23 normal samples and 32 tumor samples from the Gene Expression Omnibus (GEO). Overlapping differentially expressed genes (ODEGs) were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, followed by construction of a protein-protein interaction (PPI) network to screen hub genes. Kaplan-Meier analysis, univariate Cox analysis, multivariate Cox analysis, Wilcoxon signed-rank test, Kruskal-Wallis test, and gene set enrichment analysis (GSEA) were performed to verify the prognostic value and function of the markers we selected. The relationships among gene expression level, tumor immune cell infiltration, and immune-checkpoints were also analyzed. RESULTS: A total of 910 genes were screened out, and C3, C3AR1, HLA-DRA, and HLA-E were identified as potential tumor markers. The expression of each gene was closely associated with tumor immune cell infiltration, survival rate, and the patients’ clinical characteristics (P
- Subjects :
- 0301 basic medicine
Oncology
Kidney
medicine.medical_specialty
business.industry
Urology
medicine.medical_treatment
Immunotherapy
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Immune system
Reproductive Medicine
HLA-E
030220 oncology & carcinogenesis
Internal medicine
HLA-DRA
medicine
Original Article
KEGG
business
Survival rate
Gene
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Transl Androl Urol
- Accession number :
- edsair.doi.dedup.....328bbe0765711b4e0a59678729fafeb0