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Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African-Caribbean and Caucasian patients
- Source :
- European Journal of Cancer, European Journal of Cancer, Elsevier, 2018, 91, pp.107-115. ⟨10.1016/j.ejca.2017.12.017⟩, European Journal of Cancer, 2018, 91, pp.107-115. ⟨10.1016/j.ejca.2017.12.017⟩
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- International audience; Background - Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. Methods - From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
Linoleic acid
Databases, Factual
medicine.medical_treatment
Peri-prostatic adipose tissue
Adipose tissue
Disease
urologic and male genital diseases
chemistry.chemical_compound
Prostate cancer
0302 clinical medicine
Cell Movement
chemistry.chemical_classification
Prostatectomy
Middle Aged
Eicosapentaenoic acid
3. Good health
Adipose Tissue
Eicosapentaenoic Acid
030220 oncology & carcinogenesis
Cohort
France
Signal Transduction
medicine.medical_specialty
West Indies
Black People
White People
03 medical and health sciences
Internal medicine
Cell Line, Tumor
Paracrine Communication
medicine
Humans
Neoplasm Invasiveness
Fatty acids
Aged
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health
business.industry
Fatty acid
Prostatic Neoplasms
medicine.disease
030104 developmental biology
chemistry
Cancer aggressiveness
business
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer, European Journal of Cancer, Elsevier, 2018, 91, pp.107-115. ⟨10.1016/j.ejca.2017.12.017⟩, European Journal of Cancer, 2018, 91, pp.107-115. ⟨10.1016/j.ejca.2017.12.017⟩
- Accession number :
- edsair.doi.dedup.....328d17c881bd5645f6eda72eca2a1f34
- Full Text :
- https://doi.org/10.1016/j.ejca.2017.12.017⟩