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Long-Term Continuous Exposure to Sulfuric Acid Mist in Cynomolgus Monkeys and Guinea Pigs
- Source :
- Archives of Environmental Health: An International Journal. 27:16-24
- Publication Year :
- 1973
- Publisher :
- Informa UK Limited, 1973.
-
Abstract
- Groups of cynomolgus monkeys were exposed io sulfuric acid mist at concentrations varying from 0.38 to 4.79 mg/cu m. Particle size varied from submicronic to 4μ, mass median diameter (MMD). Groups of guinea pigs were exposed at 0.10 or 0.08 mg/cu m with MMD of 2.8, and 0.8μ, respectively. Exposures were continuous for 78 weeks in monkeys and 52 weeks in guinea pigs. The results signified no deleterious effects due to sulfuric acid mist exposure of guinea pigs. In cynomolgus monkeys, concentrations of 2.43 and 4.79 mg/cu m with particles of 3.60μ and 0.73μ MMD, respectively, were sufficient to produce definite deleterious effects on pulmonary structures and deterioration in pulmonary function. At lower concentrations the effects on pulmonary structures or deterioration in pulmonary function were less pronounced or absent. Microscopic changes observed were principally characterized by focal epithelial hyperplasia and focal thickening of the bronchiolar walls.
- Subjects :
- Lung Diseases
Male
medicine.medical_specialty
Time Factors
Guinea Pigs
Bronchi
Growth
Pulmonary function testing
Toxicology
chemistry.chemical_compound
Internal medicine
medicine
Animals
Environmental Chemistry
Particle Size
Continuous exposure
Lung
General Environmental Science
Aerosols
Hyperplasia
Hydrogen compounds
Body Weight
Public Health, Environmental and Occupational Health
Bronchial Diseases
Sulfuric acid
Environmental Exposure
Haplorhini
Hydrogen-Ion Concentration
Sulfuric Acids
Inorganic acids
Blood Cell Count
Respiratory Function Tests
Endocrinology
chemistry
Macaca
Pulmonary Diffusing Capacity
Female
Thickening
Blood Gas Analysis
Blood Chemical Analysis
Subjects
Details
- ISSN :
- 00039896
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Archives of Environmental Health: An International Journal
- Accession number :
- edsair.doi.dedup.....328f6f62a7c88f3e4b105ebfa7e296b7
- Full Text :
- https://doi.org/10.1080/00039896.1973.10666301