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Synthesis and characterization of a proton transfer salt between 2,6-pyridinedicarboxylic acid and 2-aminobenzothiazole, and its complexes and their inhibition studies on carbonic anhydrase isoenzymes
- Source :
- Journal of enzyme inhibition and medicinal chemistry. 29(3)
- Publication Year :
- 2013
-
Abstract
- WOS: 000336311600008<br />PubMed ID: 23808804<br />A novel proton transfer compound (HABT)(+)(Hdipic)(-) (1) obtained from ABT and H(2)dipic and its metal complexes (2-5) have been prepared and characterized by spectroscopic techniques. Single crystal X-ray diffraction method has also been applied to 2 and 5. While complex 2 has a distorted octahedral conformation, 5 exhibits a distorted square pyramidal structure. The structures of 3 and 4 might be proposed as octahedral according to experimental data. All compounds were also evaluated for their in vitro inhibition effects on hCA I and II for their hydratase and esterase activities. Although there is no inhibition for hydratase activities, all compounds have inhibited the esterase activities of hCA I and II. The comparison of the inhibition studies of 1-5 to parent compounds indicates that 1-5 have superior inhibitory effects. The inhibition effects of 2-5 are also compared to inhibitory properties of the metal complexes of ABT and H(2)dipic, revealing an improved transfection profile.<br />Dumlupinar University [2010/2]<br />The authors acknowledge the support provided by Dumlupinar University Research Fund (grant No. 2010/2). In addition, the authors would like to thank the Medicinal Plants and Medicine Research Center of Anadolu University, for allowing us to use the X-ray facility.
- Subjects :
- Dipicolinic Acid
Carbonic Anhydrase I
Erythrocytes
Stereochemistry
Pyridines
Carbonic anhydrase II
Crystallography, X-Ray
Esterase
Carbonic Anhydrase II
chemistry.chemical_compound
Proton Transfer
Structure-Activity Relationship
Coordination Complexes
Carbonic anhydrase
Metals, Heavy
Drug Discovery
Structure–activity relationship
Humans
Benzothiazoles
Carbonic Anhydrase Inhibitors
Picolinic Acids
Inhibition
Enzyme Assays
Pharmacology
biology
Chemistry
Hydrogen bond
Hydrogen Bonding
General Medicine
Dipicolinic acid
2-Aminobenzothiazole
Square pyramidal molecular geometry
biology.protein
Salts
Protons
Carbonic Anydrase
Subjects
Details
- ISSN :
- 14756374
- Volume :
- 29
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of enzyme inhibition and medicinal chemistry
- Accession number :
- edsair.doi.dedup.....3295a2fee7e50eda47d070ded93f5141