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Cholesterol levels in HIV–HCV infected patients treated with lopinavir/r: Results from the SCOLTA project
- Source :
- Biomedicine & Pharmacotherapy. 62:16-20
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Background: It is not known whether antiretroviral therapy (ART) including lopinavir/r has a different effect on the lipid metabolism in HIV patients co-infected with HCV. This study investigated changes in lipid levels, comparing patients with HIV infection alone and those with HCV too, in the lopinavir/r cohort of the SCOLTA project. Methods: We analyzed the data for the lopinavir/r nationwide cohort from 25 Italian infectious disease departments, which comprises 743 HIV-infected patients followed prospectively, comparing subjects with HIV-HCV co-infection and those with single-infection. Results: At enrolment, co-infected patients had significantly lower mean cholesterol than HCV negative cases (162 ± 43 mg/dL vs. 185 ± 52 mg/dL, p = 0.0009). Total and non-HDL cholesterol and triglycerides rose significantly from baseline in HIV single-infection patients, but not in those with co-infection. The patients with dual HIV-HCV infection, treated with an ART regimen including lopinavir/r, have only limited increases in total and non-HDL cholesterol and triglycerides. Conclusions: Changes in serum lipids in co-infected patients differed significantly from those in patients without HCV. It remains to be seen whether this is associated with a lower risk of progression of atherosclerotic disease. © 2007 Elsevier Masson SAS. All rights reserved.
- Subjects :
- Male
Blood lipids
HIV Infections
Triglyceride
Gastroenterology
Lopinavir
Cohort Studies
Drug Combination
HIV Infection
Prospective Studies
Prospective cohort study
Pyrimidinone
virus diseases
General Medicine
Lipid
Middle Aged
Cardiovascular disease
Antiretroviral therapy
Drug Combinations
Cholesterol
Atherosclerosi
HCV
Cohort
Female
Human
Cohort study
medicine.drug
Adult
medicine.medical_specialty
Anti-HIV Agents
Pyrimidinones
Lower risk
Follow-Up Studie
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
medicine
Humans
Triglycerides
HIV Protease Inhibitor
Pharmacology
Ritonavir
business.industry
HIV
Anti-HIV Agent
HIV Protease Inhibitors
Hepatitis C, Chronic
medicine.disease
Prospective Studie
Immunology
Cohort Studie
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....32a1cd10638c1f02d5617b599bd76128