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The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2
- Source :
- Experimental hematology. 87
- Publication Year :
- 2020
-
Abstract
- Activity of the transcription factor NFE2 is elevated in the majority of patients with myeloproliferative neoplasms (MPNs), either by overexpression of the wild-type alleles or by the presence of an activating mutation. In murine models, enhanced NFE2 activity causes an MPN phenotype with spontaneous transformation to acute leukemia. However, little is known about the downstream target genes activated by augmented NFE2 levels. Here, we describe that NFE2 regulates expression of the hematopoietic master regulators GATA2 and SCL/TAL1, which are in turn overexpressed in primary MPN cells, suggesting that concomitant aberrant activation of several transcription factors coordinately contributes to the cellular expansion characteristic of these disorders.
- Subjects :
- 0301 basic medicine
Cancer Research
NF-E2 Transcription Factor
Biology
NFE2
03 medical and health sciences
0302 clinical medicine
Genetics
Humans
Molecular Biology
Transcription factor
T-Cell Acute Lymphocytic Leukemia Protein 1
Regulation of gene expression
Myeloproliferative Disorders
GATA2
Cell Biology
Hematology
Phenotype
GATA2 Transcription Factor
Gene Expression Regulation, Neoplastic
Haematopoiesis
030104 developmental biology
030220 oncology & carcinogenesis
Hematologic Neoplasms
NF-E2 Transcription Factor, p45 Subunit
Cancer research
TAL1
Subjects
Details
- ISSN :
- 18732399
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Experimental hematology
- Accession number :
- edsair.doi.dedup.....32ad62fa0af82b35f4f2b7e884ce9204