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QTc and autonomic neuropathy in diabetes: effects of acute hyperglycaemia and n-3 PUFA
- Publication Year :
- 2007
- Publisher :
- Springer International, 2007.
-
Abstract
- Background and aims Autonomic function is also regulated by glycaemia and exerts a crucial role in the control of blood pressure and cardiac function. The disruption of this physiological mechanism impacts deeply on cardiovascular mortality in diabetes. We investigated the influence of autonomic dysfunction on QTc interval and on sympatho-vagal balance (LF/HF), in response to acute hyperglycaemia and to membrane electrical stabilization (n-3 PUFA). Methods and results Twenty-four type 2 diabetic patients, without (N−: n = 13) or with (N+: n = 11) autonomic neuropathy and 13 healthy subjects (C) underwent BP and ECG monitoring during a 24-h period and during a 2-h hyperglycaemic clamp. ΔQTc during the night was blunted in diabetics (0.5 ± 2.5 vs. C: 2.9 ± 2.5%, p = 0.001), and ΔLF/HF was decreased in N+ (−2.8 ± 38.2 vs. C = 34.8 ± 28.1%, p = 0.02). During hyperglycaemia, QTc increased in C; LF/HF significantly increased in C and N−. A 6-month treatment with n-3 PUFA partially restored ΔLF/HF and ΔQTc (2.1 ± 1.40, p = 0.04 vs. basal) only in N−. Conclusion Hyperglycaemia increases QTc interval and sympathetic activity; electrical membrane stabilization improves autonomic function only in the absence of overt autonomic neuropathy. Strategies to prevent the disruption of autonomic function with newer approaches, other than just glucose control, should be implemented.
- Subjects :
- Male
Cardiac function curve
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Blood Pressure
Autonomic Nervous System
QT interval
Settore MED/13 - Endocrinologia
Diabetes Complications
Electrocardiography
Diabetic Neuropathies
Heart Rate
Diabetes mellitus
Internal medicine
Fatty Acids, Omega-3
Humans
Medicine
Nutrition and Dietetics
medicine.diagnostic_test
business.industry
Middle Aged
Glucose clamp technique
medicine.disease
Blood pressure
Endocrinology
Autonomic Nervous System Diseases
Diabetes Mellitus, Type 2
Basal (medicine)
Hyperglycemia
Heart Function Tests
Glucose Clamp Technique
Female
Cardiology and Cardiovascular Medicine
business
Autonomic neuropathy
Subjects
Details
- Language :
- English, Middle (1100-1500)
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....32caede6863b59597f7fd1491ab111e2