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The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias
- Source :
- Cancer letters, 357 (2015): 535–541. doi:10.1016/j.canlet.2014.12.010, info:cnr-pdr/source/autori:Leone V.; Ferraro A.; Schepis F.; Federico A.; Sepe R.; Arra C.; Langella C.; Palma G.; De Lorenzo C.; Troncone G.; Masciullo V.; Scambia G.; Fusco A.; Pallante P./titolo:The cl2%2Fdro1%2Fccdc80 null mice develop thyroid and ovarian neoplasias/doi:10.1016%2Fj.canlet.2014.12.010/rivista:Cancer letters (Print)/anno:2015/pagina_da:535/pagina_a:541/intervallo_pagine:535–541/volume:357
- Publication Year :
- 2015
- Publisher :
- Elsevier Scientific Publishers Ireland, Shannon , Paesi Bassi, 2015.
-
Abstract
- We have previously reported that the expression of the CL2/CCDC80 gene is downregulated in human papillary thyroid carcinomas, particularly in follicular variants. We have also reported that the restoration of CL2/CCDC80 expression reverted the malignant phenotype of thyroid carcinoma cell lines and that CL2/CCDC80 positively regulated E-cadherin expression, an ability that likely accounts for the role of the CL2/CCDC80 gene in thyroid cancer progression. In order to validate the tumour suppressor role of the CL2/CCDC80 gene in thyroid carcinogenesis we generated cl2/ccdc80 knock-out mice. We found that embryonic fibroblasts from cl2/ccdc80 −/− mice showed higher proliferation rate and lower susceptibility to apoptosis. Furthermore, cl2/ccdc80 −/− mice developed thyroid adenomas and ovarian carcinomas. Finally, ret/PTC1 transgenic mice crossed with the cl2/ccdc80 knock-out mice developed more aggressive thyroid carcinomas compared with those observed in the single ret/PTC1 transgenic mice. Together, these results indicate CL2/CCDC80 as a putative tumour suppressor gene in human thyroid carcinogenesis.
- Subjects :
- Male
Cancer Research
Oncogene Proteins, Fusion
endocrine system diseases
Apoptosis
Colorectal Neoplasm
medicine.disease_cause
Protein-Tyrosine Kinase
Intercellular Signaling Peptides and Protein
Knock-out mice
Thyroid cancer
Cells, Cultured
Thyroid Neoplasm
Ovarian Neoplasms
Mice, Knockout
Thyroid
Extracellular Matrix Proteins
Reverse Transcriptase Polymerase Chain Reaction
Protein-Tyrosine Kinases
Cl2/dro1/ccdc80
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Oncology
Knockout mouse
Intercellular Signaling Peptides and Proteins
Female
Colorectal Neoplasms
Breast Neoplasm
Human
Genetically modified mouse
medicine.medical_specialty
endocrine system
Breast Neoplasms
Ovary
Mice, Transgenic
Biology
Thyroid carcinoma
Internal medicine
medicine
Carcinoma
Animals
Humans
Thyroid Neoplasms
thyroid and ovarian neoplasias
Glycoproteins
Cell Proliferation
cl2/dro1/ccdc80
Animal
Ovarian Neoplasm
Tumor Suppressor Proteins
Apoptosi
medicine.disease
Embryo, Mammalian
Carcinoma, Papillary
Endocrinology
Settore MED/40 - GINECOLOGIA E OSTETRICIA
Cancer research
Glycoprotein
Carcinogenesis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cancer letters, 357 (2015): 535–541. doi:10.1016/j.canlet.2014.12.010, info:cnr-pdr/source/autori:Leone V.; Ferraro A.; Schepis F.; Federico A.; Sepe R.; Arra C.; Langella C.; Palma G.; De Lorenzo C.; Troncone G.; Masciullo V.; Scambia G.; Fusco A.; Pallante P./titolo:The cl2%2Fdro1%2Fccdc80 null mice develop thyroid and ovarian neoplasias/doi:10.1016%2Fj.canlet.2014.12.010/rivista:Cancer letters (Print)/anno:2015/pagina_da:535/pagina_a:541/intervallo_pagine:535–541/volume:357
- Accession number :
- edsair.doi.dedup.....32d3b1de96bcc09a2e06c7de81811770