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Patterns of brain atrophy in clinical variants of frontotemporal lobar degeneration
- Source :
- Dementia and geriatric cognitive disorders, vol 35, iss 1-2
- Publication Year :
- 2013
- Publisher :
- eScholarship, University of California, 2013.
-
Abstract
- Background/Aims: The clinical syndromes of frontotemporal lobar degeneration include behavioral variant frontotemporal dementia (bvFTD) and semantic (SV-PPA) and nonfluent variants (NF-PPA) of primary progressive aphasia. Using magnetic resonance imaging (MRI), tensor-based morphometry (TBM) was used to determine distinct patterns of atrophy between these three clinical groups. Methods: Twenty-seven participants diagnosed with bvFTD, 16 with SV-PPA, and 19 with NF-PPA received baseline and follow-up MRI scans approximately 1 year apart. TBM was used to create three-dimensional Jacobian maps of local brain atrophy rates for individual subjects. Results: Regional analyses were performed on the three-dimensional maps and direct comparisons between groups (corrected for multiple comparisons using permutation tests) revealed significantly greater frontal lobe and frontal white matter atrophy in the bvFTD relative to the SV-PPA group (p < 0.005). The SV-PPA subjects exhibited significantly greater atrophy than the bvFTD in the fusiform gyrus (p = 0.007). The NF-PPA group showed significantly more atrophy in the parietal lobes relative to both bvFTD and SV-PPA groups (p < 0.05). Percent volume change in ventromedial prefrontal cortex was significantly associated with baseline behavioral symptomatology. Conclusion: The bvFTD, SV-PPA, and NF-PPA groups displayed distinct patterns of progressive atrophy over a 1-year period that correspond well to the behavioral disturbances characteristic of the clinical syndromes. More specifically, the bvFTD group showed significant white matter contraction and presence of behavioral symptoms at baseline predicted significant volume loss of the ventromedial prefrontal cortex.
- Subjects :
- Male
Pathology
Aging
Image Processing
Neuropsychological Tests
Neurodegenerative
Primary progressive aphasia
Executive Function
Cognition
Computer-Assisted
Image Processing, Computer-Assisted
Longitudinal Studies
Alzheimer's Disease Related Dementias (ADRD)
Language
White matter
Brain
Frontotemporal lobar degeneration
respiratory system
Middle Aged
Magnetic Resonance Imaging
Psychiatry and Mental health
Frontotemporal Dementia (FTD)
medicine.anatomical_structure
Diffusion Tensor Imaging
Frontal lobe
Neurological
Disease Progression
Biomedical Imaging
Female
Cognitive Sciences
Longitudinal study
Psychology
Algorithms
Frontotemporal dementia
medicine.medical_specialty
Cognitive Neuroscience
Clinical Sciences
Ventromedial prefrontal cortex
Article
Atrophy
Rare Diseases
Magnetic resonance imaging
Clinical Research
Behavioral and Social Science
medicine
Acquired Cognitive Impairment
Aphasia
Humans
Aged
Behavior
Neurosciences
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)
Tensor-based morphometry
medicine.disease
Brain Disorders
Geriatrics
Dementia
Geriatrics and Gerontology
Frontotemporal Lobar Degeneration
Psychomotor Performance
Diffusion MRI
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dementia and geriatric cognitive disorders, vol 35, iss 1-2
- Accession number :
- edsair.doi.dedup.....32dea5973ecaa7655168955a003a5f25